International Takotsubo Registry (InterTAK Registry)

Conditions

Takotsubo Cardiomyopathy

Keywords

Broken heart syndrome, stress cardiomyopathy

Brief summary

This is a multicenter, multinational, prospective and retrospective, observational study of patients with Takotsubo cardiomyopathy (TTC). Data on natural profile (demographical characteristics, clinical phenotype, laboratory values, electrocardiography parameters, echocardiography parameters, coronary angiography parameters, medication) and outcome are systematically collected. Our aim is to gain a better insight into the clinical profile and pathophysiology of TTC.

Detailed description

Registry is an open-ended study and eligible individuals are assessed at index event and follow-up on their phenotypical characteristics. Furthermore, outcome data are collected (by clinical visits or telephone follow-up). In addition, participants are given the option to consent to the donation of biosamples for the purposes to identify TTC specific biomarkers and mutations (sub-study on behalf of the registry).

Wenzl FA, Schweiger V, Smolle MA, Zech D, Akhmedov A, Wang P, Lapikova-Bryhinska T, Wang Y, Liberale L, Santos K, Ilina Y, Kraler S, Bergmann A, Kaufmann P, Kahles F, von Eckardstein A, Roffi M, Räber L, Cammann VL, Ghadri JR, Di Vece D, Lüscher TF, Templin C, InterTAK and SPUM-ACS investigators.

2026-08-31

10.1093/eurheartj/ehag597

Body weight and mortality in Takotsubo syndrome: insights from the International Takotsubo (InterTAK) Registry

Barbara E Stähli, Victor Schweiger, Victoria L. Cammann, Julia Kebernik, Konrad A. Szawan et al. (19 authors)

Open Heart2026-01-01

10.1136/openhrt-2025-003851

Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome.

Cammann VL, Scheitz JF, von Rennenberg R, Jäncke L, Nolte CH, Szawan KA, Stengl H, Würdinger M, Endres M, Templin C, Ghadri JR, InterTAK Consortium.

2021-12-0721 citations

10.1038/s41598-021-01496-9

Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry

Ibrahim El‐Battrawy, Victoria L. Cammann, Ken Kato, Konrad A. Szawan, Davide Di Vece et al. (100 authors)

Journal of the American Heart Association2021-07-2840 citations

10.1161/jaha.119.014059

Clinical characteristics and outcomes of patients with takotsubo syndrome versus spontaneous coronary artery dissection

Victoria L. Cammann, Annahita Sarcon, Konrad A. Szawan, Michael Würdinger, Saif Azam et al. (10 authors)

Cardiology Journal2021-06-2410 citations

10.5603/cj.a2021.0065

Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry

Yoichi Imori, Ken Kato, Victoria L. Cammann, Konrad A. Szawan, Manfred Wischnewsky et al. (100 authors)

Clinical Research in Cardiology2021-05-1928 citations

10.1007/s00392-021-01857-4

Coexistence and outcome of coronary artery disease in Takotsubo syndrome

L. Christian Napp, Victoria L. Cammann, Miłosz Jaguszewski, Konrad A. Szawan, Manfred Wischnewsky et al. (94 authors)

European Heart Journal2020-03-1683 citations

10.1093/eurheartj/ehaa210

Impact of Aspirin on Takotsubo Syndrome: A Propensity Score-Based Analysis of the InterTAK Registry

Fabrizio D’Ascenzo, Sebastiano Gili, Maurizio Bertaina, Mario Iannaccone, Victoria L. Cammann et al. (85 authors)

European Journal of Heart Failure2019-12-2045 citations

10.1002/ejhf.1698

Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome

Katharina J. Ding, Victoria L. Cammann, Konrad A. Szawan, Barbara E. Stähli, Manfred Wischnewsky et al. (86 authors)

Arteriosclerosis Thrombosis and Vascular Biology2019-11-2664 citations

10.1161/atvbaha.119.313491

Clinical Predictors and Prognostic Impact of Recovery of Wall Motion Abnormalities in Takotsubo Syndrome: Results From the International Takotsubo Registry.

Jurisic S, Gili S, Cammann VL, Kato K, Szawan KA, D'Ascenzo F, Jaguszewski M, Bossone E, Citro R, Sarcon A, Napp LC, Franke J, Noutsias M, Knorr M, Heiner S, Burgdorf C, Koenig W, Pott A, Kherad B, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Dworakowski R, Kaiser C, Osswald S, Galiuto L, Dichtl W, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Kozel M, Tousek P, Winchester DE, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Galuszka J, Ukena C, Poglajen G, Paolini C, Bilato C, Carrilho-Ferreira P, Pinto FJ, Opolski G, MacCarthy P, Kobayashi Y, Prasad A, Rihal CS, Widimský P, Horowitz JD, Di Mario C, Crea F, Tschöpe C, Pieske BM, Hasenfuß G, Rottbauer W, Braun-Dullaeus RC, Felix SB, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Schunkert H, Münzel T, Böhm M, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C.

2019-11-0129 citations

10.1161/jaha.118.011194

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.

Cammann VL, Sarcon A, Ding KJ, Seifert B, Kato K, Di Vece D, Szawan KA, Gili S, Jurisic S, Bacchi B, Micek J, Frangieh AH, Napp LC, Jaguszewski M, Bossone E, Citro R, D'Ascenzo F, Franke J, Noutsias M, Knorr M, Heiner S, Burgdorf C, Koenig W, Thiele H, Tschöpe C, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Dworakowski R, Kaiser C, Osswald S, Galiuto L, Dichtl W, Delmas C, Lairez O, Horowitz JD, Kozel M, Widimský P, Tousek P, Winchester DE, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Ukena C, Bauersachs J, Pieske BM, Hasenfuß G, Rottbauer W, Braun-Dullaeus RC, Opolski G, MacCarthy P, Felix SB, Borggrefe M, Di Mario C, Crea F, Katus HA, Schunkert H, Münzel T, Böhm M, Bax JJ, Prasad A, Shinbane J, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C.

2019-07-1751 citations

10.1161/jaha.118.010881

Long-Term Prognosis of Patients With Takotsubo Syndrome.

Ghadri JR, Kato K, Cammann VL, Gili S, Jurisic S, Di Vece D, Candreva A, Ding KJ, Micek J, Szawan KA, Bacchi B, Bianchi R, Levinson RA, Wischnewsky M, Seifert B, Schlossbauer SA, Citro R, Bossone E, Münzel T, Knorr M, Heiner S, D'Ascenzo F, Franke J, Sarcon A, Napp LC, Jaguszewski M, Noutsias M, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuß G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Horowitz J, Kozel M, Tousek P, Widimský P, Gilyarova E, Shilova A, Gilyarov M, Winchester DE, Ukena C, Bax JJ, Prasad A, Böhm M, Lüscher TF, Ruschitzka F, Templin C.

2018-08-01243 citations

10.1016/j.jacc.2018.06.016

Interaction of Systolic Blood Pressure and Resting Heart Rate with Clinical Outcomes in Takotsubo Syndrome: Insights from the International Takotsubo Registry

Michael Böhm, Victoria L. Cammann, Jelena R. Ghadri, Christian Ukena, Sebastiano Gili et al. (18 authors)

European Journal of Heart Failure2018-03-0835 citations

10.1002/ejhf.1162

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy.

Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K.

2017-08-01124 citations

10.1016/j.jacc.2017.06.061

ECG Criteria to Differentiate Between Takotsubo (Stress) Cardiomyopathy and Myocardial Infarction

Antonio H. Frangieh, Slayman Obeid, Jelena R. Ghadri, Yoichi Imori, Fabrizio D’Ascenzo et al. (23 authors)

Journal of the American Heart Association2016-06-13166 citations

10.1161/jaha.116.003418

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

Christian Templin, Jelena R. Ghadri, Johanna Diekmann, L. Christian Napp, Dana Roxana Bataiosu et al. (67 authors)

New England Journal of Medicine2015-09-022,446 citations

10.1056/nejmoa1406761

Interventions

None listed

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

Mayo Clinic Diagnostic Criteria (Prasad et al. American Heart Journal 2008) 1. Transient hypokinesis, akinesis, or dyskinesis of the left ventricular mid segments with or without apical involvement; the regional wall motion abnormalities extend beyond a single epicardial vascular distribution; a stressful trigger is often, but not always present.\* 2. Absence of obstructive coronary disease or angiographic evidence of acute plaque rupture. † 3. New electrocardiographic abnormalities (either ST-segment elevation and/or T-wave inversion) or modest elevation in cardiac troponin. In both of the above circumstances, the diagnosis of TTC should be made with caution, and a clear stressful precipitating trigger must be sought. \* There are rare exceptions to these criteria such as those patients in whom the regional wall motion abnormality is limited to a single coronary territory. † It is possible that a patient with obstructive coronary atherosclerosis may also develop TTC.

Exclusion criteria

Patients with Myocarditis

Design outcomes

Primary

Measure	Time frame	Description
Natural history of TTC	10 years	To determine the natural history of Takotsubo cardiomyopathy.

Secondary

Measure	Time frame	Description
Cardiovascular complications, recurrence of TTC and all cause mortality	at hospitalizsation, short term (1 year) and long term (10 years)	Patients will be assessed for cardiovascular complications during hospitalisation and at follow-up (up to 10 years)

Countries

Switzerland

Contacts

Primary ContactChristian Templin, MD, PhD

christian.templin@usz.ch+41 44 255 95 85

Outcome results