Abdominal Aortic Aneurysm, Cardiac Arrest, Sudden Cardiac Death, Coronary Heart Disease NOS, Heart Failure, Intracerebral Haemorrhage, Ischemic Stroke, Myocardial Infarction, Peripheral Arterial Disease, Stable Angina Pectoris, Stroke, Subarachnoid Haemorrhage, Transient Ischemic Attack, Unheralded Coronary Death, Unstable Angina
Conditions
Brief summary
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
Detailed description
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Interventions
None listed
Sponsors
Wellcome Trust
National Institute for Health Research, United Kingdom
University College, London
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* One year prior to study entry (up-to-standard follow-up, CPRD quality research standard). * \> 30 years old * have at least a recorded heart rate measurement during the study period
Exclusion criteria
\- Evidence of prior atherosclerotic or cardiac disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk of atherosclerotic disease in patients with high or low heart rate | Participants were followed until the first Coronary disease event (an expected average of 5 years) | Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by: * by sex * gender * a range of risk factors (such as physical activity, smoking status, drinking status, etc.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence proportions and life time risk for Cardiovascular diseases | Participants were followed until the first Coronary disease event (an expected average of 5 years) | Subhazard Ratios and Cumulative Incidence estimation of the risk of 12 different cardiovascular diseases adjusted for the 4 different levels of heart rate (\<60, 60-74, 75-89, \>90), age and sex in a lifetime period |
Countries
United Kingdom
Outcome results
None listed