Potentially Inappropriate Medications
Conditions
Keywords
Potentially inappropriate medications, Elderly, Prevention, Multidisciplinary program, Checklist, Stepped wedge design, AGED, 75 AND OVER
Brief summary
Drug prescription is a fundamental component of care for the elderly. Even if drugs are a chance for the older patient, because of changes in pharmacological, pharmacokinetic and pharmacodynamic parameters related with age and acute/or chronic pathologies, the risks associated with drug prescription, particularly those associated with potentially inappropriate medication (PIM), are increased in the elderly. We suppose that many of hospitalized elderly have at least one prescribed medication without valid indication. Conversely, many diseases are currently undertreated in elderly patients: e.g. medicines used to treat heart failure and osteoporosis are underused in 20 to 70% of patients. Moreover, PMI prescription is associated with an increased of morbidity, mortality, risk of drug-related adverse events, utilization of health care system, care costs and impairment of quality of life. Thus, optimization of drug prescription is a major concern for improvement of the quality and safety of care in elderly. The investigators' hypothesis is that a multidisciplinary program entitled Optimisation de la Prescription MEDicamenteuse (Optimization of drug prescribing) focused on drug prescription optimization including a physician training to the specificity of the drug prescription in the elderly and a checklist allowing an adapted and standardized pharmaceutical analysis is effective in reducing PIM in elderly patients hospitalized in short-term medical and geriatric care departments.
Interventions
OTHER Optimisation de la Prescription MEDicamenteuse (Optimization of drug prescribing)
The multidisciplinary intervention program include: * Awareness and training of doctors by two experts (a geriatrician and a pharmacist) within participating departments. * Implementation of a checklist which aims to conduct an adapted and standardized pharmaceutical analysis
Sponsors
Hospices Civils de Lyon
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
75 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female subject aged over 75 years hospitalized in one of the participating department * Patient agreed to participate
Exclusion criteria
* Patient with a predictive length of stay equal or less than 48 hours * Patients admitted in terminal illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of potentially inappropriate medications (PIM) prescribed in discharge of hospitalized patients from 75 years old. | at discharge (average 3 weeks) | Proportion of prescribed PIM will be expressed as the ratio of PIM to the total number of medication in discharge prescription sheet. PIM will be identified by 2 experts (1 doctor and 1 pharmacist) based on criteria from the lists STOPP/START and Laroche. |
Secondary
| Measure | Time frame |
|---|---|
| Total number of drugs prescribed per discharge prescription sheet | at discharge (average 3 weeks) |
| Number of rehospitalization within 12 months following discharge | 12 months after inclusion |
| Number of emergency admission within 12 months following hospitalization | 12 months after inclusion |
| Mortality within 12 months after hospitalization | 12 months after inclusion |
Countries
France
Outcome results
None listed