Gene Expression in Patients With Epiretinal Membranes

Gene Expression and Their Correlations in Patients With Idiopathic and Secondary Epiretinal Membranes in Proliferative Diabetic Retinopathy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01946451

Enrollment

Unknown

Registered

2013-09-19

Start date

2012-06-30

Completion date

2013-12-31

Last updated

2013-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proliferative Diabetic Retinopathy

Keywords

idiopathic epiretinal membranes, secondary epiretinal membranes

Brief summary

The purpose of this study was to investigate the expression of selected genes both in epiretinal membranes (ERMs) and peripheral blood mononuclear cells (PBMCs) from patients with primary and secondary epiretinal membranes in proliferative diabetic retinopathy. Possible correlations between messenger ribonucleic acid (mRNA) levels of these genes were also identified.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

* Caucasian race, * both males and females, * aged ≥ 55 years, * suffering from idiopathic ERMs or secondary ERMs in proliferative diabetic retinopathy (PDR). * Presence of ERM was proven in optical coherence tomography (OCT) examination.

Exclusion criteria

* aged \< 55 years, * systemic connective tissue disease, * active inflammatory process

Design outcomes

Primary

Measure	Time frame
Gene expression in patients with idiopathic and secondary epiretinal membranes in proliferative diabetic retinopathy.	The period between the diagnosis of the ERMs and the actual surgery for the condition was between 2 and 43 months.

Countries

Poland

Outcome results