Patients With Elective Aortic Valve Replacement
Conditions
Keywords
Remote ischemic preconditioning, cardiac surgery, left ventricular hypertrophy, reperfusion injury salvage kinase
Brief summary
The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium
Interventions
PROCEDURERemote ischemic preconditioning at left upper arm
Placement of automated cuff-inflator on the left upper arm after induction of anesthesia RIPCgroup-3 cycles of 5 min ischemia (300 mmHg inflation) & 5 min reperfusion (deflation)
PROCEDUREControl group
keeping the cuff deflated
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR
Exclusion criteria
* diabetes mellitus, * coronary stenosis ≥70%, * renal failure (serum creatinine \> 2.0 mg/dL), * upper arm peripheral vascular disease, * LV ejection fraction \<50%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of CK-MB and Tn-T | baseline |
Secondary
| Measure | Time frame |
|---|---|
| Myocardial activation of protective signaling pathway | Before commencement of CPB |
Countries
South Korea
Outcome results
None listed