Chronic Liver Disease, Cirrhosis
Conditions
Keywords
Peptic ulcer, Liver cirrhosis, Portal hypertension
Brief summary
The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.
Detailed description
Retrospective case-control study * Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008\ 2012. * Portal hypertension is assessed using HVPG measurement via transjugular approach. * Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement * The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis * There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.
Interventions
None listed
Sponsors
Chuncheon Sacred Heart Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patients who underwent hepatic vein pressure gradient (HVPG) measurement and esophagogastroduodenoscopy (EGD) and also had LC or chronic hepatitis
Exclusion criteria
* The patients who have missing or incomplete HVPG or EGD data * The patients who underwent gastrectomy * The patients who have systemic malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Association of HVPG and PUD in Patients With Liver Cirrhosis | Retrospective case-control study (from 2009 to 2012, up to 3 years) | The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software. |
Secondary
| Measure | Time frame |
|---|---|
| The Association Between PUD and HVPG in Patients With Chronic Hepatitis | Retrospective case-control study (from 2009 to 2012, up to 3 years) |
Countries
South Korea
Participant flow
Recruitment details
We analyzed the medical records of 455 hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) patients who had LC or chronic hepatitis in a single tertiary hospital.
Pre-assignment details
800 HVPG measurement cases (Initial). Missing data (3), failure of HVPG measurements (8), cases without EGD (196); including 35 cases of patients on B-blocker, EGD over 3 months from HVPG measurement (79), incomplete EGD due to remnant food materials (19), cases having a history of gastrectomy (5), acute hepatopathy (5), and HCC (30) were excluded.
Participants by arm
| Arm | Count |
|---|---|
| Patients With Chronic Hepatitis Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | 127 |
| Patients With Liver Cirrhosis Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement | 328 |
| Total | 455 |
Baseline characteristics
| Characteristic | Patients With Chronic Hepatitis | Patients With Liver Cirrhosis | Total |
|---|---|---|---|
| Age, Continuous | 45 years | 52 years | 50 years |
| alcoholc | 56 participants | 233 participants | 289 participants |
| HVPG (mmHg) | 3.5 mmHg | 15 mmHg | 12 mmHg |
| Medication (NSAIDs, aspirin, clopidogrel, ticlopidine, steroid) | 7 participants | 16 participants | 23 participants |
| PUD | 13 participants | 59 participants | 72 participants |
| Sex: Female, Male Female | 46 Participants | 70 Participants | 116 Participants |
| Sex: Female, Male Male | 81 Participants | 258 Participants | 339 Participants |
| smoking | 39 participants | 164 participants | 203 participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 127 | 0 / 328 |
| serious Total, serious adverse events | 0 / 127 | 0 / 328 |
Outcome results
Primary
The Association of HVPG and PUD in Patients With Liver Cirrhosis
The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software.
Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| PUD in Liver Cirrhosis | The Association of HVPG and PUD in Patients With Liver Cirrhosis | 14.5 mmHg |
| No PUD in Liver Cirrhosis | The Association of HVPG and PUD in Patients With Liver Cirrhosis | 15.3 mmHg |
Secondary
The Association Between PUD and HVPG in Patients With Chronic Hepatitis
Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| PUD in Liver Cirrhosis | The Association Between PUD and HVPG in Patients With Chronic Hepatitis | 3.7 mmHg |
| No PUD in Liver Cirrhosis | The Association Between PUD and HVPG in Patients With Chronic Hepatitis | 3.4 mmHg |