Colorectal Neoplasms
Conditions
Brief summary
This study is aimed to analyze the outcomes after conventional endoscopic submucosal dissection (ESD) and optimized ESD with snaring (oESD-S) for colorectal neoplasm that is more than 20 mm in diameter of laterllay spreading tumor or flat elevated lesion without stalk. Optimized ESD with snaring means submucosal dissection followed by snaring when narrowed circumference of the remained submucosal tissue beneath the lesion is less than 5 mm in diameter with snaring, then resected by using an electric current. The investigators expect optimized ESD with snaring can provide more time-saving procedure with comparable en-bloc resection rate and perforation rate, when compared with the conventional ESD method.
Interventions
PROCEDUREOptimized ESD with snaring
PROCEDUREConventional ESD
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* colorectal laterally spreading tumor that is more than 20 mm in diameter * other elevated or flat colorectal neoplasm without stalk, that is more than 20 mm in diameter
Exclusion criteria
* colorectal neoplasms that are proven or suspected to be invaded more than submucosal invasion * colorectal neoplasms that have severe fibrosis beneath the target lesion * patient's refusal to participate this study * less than 18 years old * subjects who cannot consent voluntarily due to the communication difficulty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| En Bloc resection rate | 8 months |
| procedure time | 8 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| histologic complete resection rate | 8 months | — |
| complication rate | 8 months | perforation rate, bleeding rate |
Countries
South Korea
Contacts
Primary ContactJeong-Sik Byeon, MD
Outcome results
None listed