Pulmonary Rehabilitation in COPD: Effects of Two Aerobic Exercise Intensity in Patient-centered Outcomes

Pulmonary Rehabilitation in COPD: Effects of Two Aerobic Exercise Intensity in Patient-centered Outcomes - a Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01944072

Enrollment

Registered

2013-09-17

Start date

2009-09-30

Completion date

2010-03-31

Last updated

2013-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic Obstructive Pulmonary Disease, COPD, Pulmonary rehabilitation, Aerobic exercise, CEDOC, FCM, UNL, NOVA MEDICAL SCHOOL

Brief summary

Trial design: An equivalence/non-inferiority randomized controlled trial with parallel group design studied the effect of two aerobic exercise-training intensities in COPD patient-centered outcomes. Methods: Thirty-four COPD clinically stable patients stratified from mild to very severe GOLD stages, were blinded to 60 or 80%Wmax aerobic exercise training intensity in an outpatient pulmonary rehabilitation program, between 2009-2010. Outcomes were assessed with St.George's respiratory questionnaire (primary outcome), Mahler dyspnea index, London Chest activity of daily living scale, 6-minute walk, constant load and incremental exercise tests. Patient's allocation sequence was computer-generated, with consignment in a safe deposit box.

Interventions

OTHERAerobic exercise training intensity

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinically stable COPD * FEV1/FVC \< 70% * Exercise training medical referral

Exclusion criteria

* Unable to attend 3-times/week program * Infectious disease * Metastatic cancer * Unstable heart disease * Neuromusculoskeletal disorder * Cognitive or psychiatric disorder

Design outcomes

Primary

Measure	Time frame
Health-related quality-of-life measured by the St.George's respiratory questionnaire	8 weeks (20 sessions)

Secondary

Measure	Time frame	Description
Symptoms control measured by the Mahler dyspnea index	8 weeks (20 sessions)	—
Exercise Tolerance	8 weeks (20 sessions)	exercise tolerance assessed by the London-Chest activity of daily-living scale, 6-minute walk test, incremental exercise test and constant-load exercise test

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 4, 2026