Chronic Rhinosinusitis
Conditions
Keywords
endoscopic sinus surgery, post-operative irrigation, pain, debridement
Brief summary
Nasal saline is a common treatment adjunct in the post-operative setting for endoscopic sinus surgery. However, the ideal timing and quantity of irrigation in the early post-operative period remains unknown. Proposed benefits of early, large volume irrigation include removal and softening of crusts, resulting in improved mucociliary clearance. The potential benefit of early large volume saline irrigation on post-operative day three to ease or reduce the need for early post-operative debridement has not been studied.
Interventions
OTHEREarly saline irrigation
Initiation of post-operative saline irrigation earlier during the post-operative course
OTHERRoutine Irrigation
Routine initiation of saline irrigation
Sponsors
University of Alberta
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients * Diagnosis of CRS with or without polyposis * Undergoing bilateral endoscopic sinus surgery * Availability of pre-operative CT paranasal sinuses
Exclusion criteria
Patients with diagnosis of: * Primary ciliary dyskinesia * Immunodeficiency * Cystic fibrosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain | Early post-operative (Day 10) | Pain and discomfort during early post-operative debridement on post-operative day 10 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endoscopic appearance | Early (post-operative day 10) | Early post-operative POSE score on post-operative day 10 |
| Late endoscopic appearance at 6 months | 6 months | Late post-operative endoscopic POSE score at 6 months |
Outcome results
None listed