EEG; Spikes, Centrotemporal, Epilepsy of Childhood, Intrauterine Growth Restriction, Neurodevelopmental Disorder, Premature - Weight 1000g-2499g or Gestation of 28-37weeks
Conditions
Keywords
IUGR, aEEG, preterm infants, neurodevelopmental outcome
Brief summary
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies. Throughout this analysis, the influence of IUGR on the postnatal amplitude-integrated EEG (aEEG) in preterm infants below 30 weeks of gestation was assessed. The second concern was the correlation between the pattern of the aEEG in the first two weeks with neurodevelopmental outcome, comparing infants with and without IUGR. Methods: Routinely assessed aEEG data of preterm infants with IUGR born below 30 weeks of gestation in the years 2005 until 2007 were analysed retrospectively according to the aEEG score (combining occurrence of sleep-wake-cycles, background activity and suspected seizure activity). Neurodevelopmental outcome was evaluated at 24 months using the Bayley Scales of Infant Development and standardized neurologic examination.
Interventions
OTHERaEEG
The amplitude integrated EEG was performed using a single-channel, biparietal aEEG (CFM 6000; Natus Medical Incorporated, San Carlos, CA)
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
23 Weeks to 30 Weeks
Healthy volunteers
No
Inclusion criteria
* preterm infants below 30 weeks of gestation
Exclusion criteria
* congenital anomalies * severe asphyxia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| aEEG score (including background pattern, occurrence of sleep-wake-cycling and presence of seizure activity) | first 14 days of life | composite score background activity (BA), occurrence of sleep-wake-cycling (SWC) and presence of seizure activity (SA) meaning score 1= normal (normal BA, SWC yes, SA no) and score 2 and 3 = abnormal (2=abnormality in 1 category (BA, SWC or SA) and score 3= abnormality in 2 or 3 categories |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurodevelopmental outcome | 24 months | composite score: Bayley Scales of Infant Development (\>85= normal, \<70 severely impaired, 71-84= mildly impaired) and standardized neurologic examination (normal or abnormal) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Morbidity, mortality and neurodevelopmental outcome of patients with IUGR compared to controls | 24 months | morbidities until discharge (Intraventricular hemorrhage, retinopathy, chronic lung disease, necrotizing enterocolitis, periventricular leucomalacia); mortality and neurodevelopmental outcome (via Bayley Scales of Infant Development \>85= normal, \<70 = severly impaired) |
Countries
Austria
Outcome results
None listed