Fatty Acid Levels and Memory in Breastfed Children

The Influence of FADS2 rs 174575 on Breastmilk Fatty Acid Levels and the Recognition Memory Abilities of 6-month Old Breastfed Infants and Follow-up

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01942434

Enrollment

202

Registered

2013-09-16

Start date

2010-01-31

Completion date

2016-08-31

Last updated

2020-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Development

Keywords

Fatty acids, Breast milk nutrients, Cognitive development, Electrophysiology, Long-term assessment

Brief summary

Purpose: To explore the relation between breastmilk nutrients and the cognitive abilities of breastfed infants. Phase 1: Near 3 months of age child and mother saliva samples for DNA obtained with breast milk sample. Phase 2: At 6 months of age child participates in electrophysiology session to test recognition memory. Phase 3: At 26 or 38 months of age, children will complete behavioral, dietary, and physical assessments.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

3 Months to 4 Months

Healthy volunteers

Yes

Inclusion criteria

* typically-developing * exclusively breastfed * unremarkable delivery

Exclusion criteria

* non-English speaking * history of seizure activity

Design outcomes

Primary

Measure	Time frame	Description
Relation between recognition memory and maternal FADS genotype	6 months	At 6 months of age, during the second session (Phase 2)

Secondary

Measure	Time frame	Description
Nutrient content of breastmilk as it relates to FADS genotype	3 to 4 months	Sample provided in session 1 when the infant was 3-4 months old (Phase 1)
Nutrient content of breastmilk as it relates to recognition memory	6 months	At 6 months of age, during the second session (Phase 2)
Relation between declarative memory and breastmilk nutrients	26 or 38 months	At session 3, when the child was either 26 or 38 months of age (Phase 3)
Relation between declarative memory and concurrent nutrients	26 or 38 months	At session 3, when the child was either 26 or 38 months of age (Phase 3)

Countries

United States

Outcome results