Ocular Surface Disease
Conditions
Keywords
Limbal deficiency, Cultivated limbal transplantation, Ex vivo limbal transplantation, Cultivated autologous mucosal epithelial transplantation
Brief summary
The purpose of this study is to elucidate the appropriate condition of developing cultivated autologous oral mucosal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated cells in the patients.
Detailed description
Ocular surface damage caused by severe ocular surface diseases. Corneal limbal stem cell transplantation has been demonstrated to improve the outcome of ocular surface reconstruction. However, the conventional management of allograft limbal transplantation generally has unsatisfactory outcome because of high risk of rejection and requires long-life immunosuppressive medications. Ocular surface reconstruction with cultivated autologous mucosal epithelial transplantation is served to improve the surgical results of ocular surface reconstruction and decrease the use of immunosuppressive medications
Interventions
PROCEDURECultivated mucosal epithelial transplantation
cultivated autologous mucosal epithelium, then transplant to limbal stem cell deficiency patients.
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Bilateral limbal stem cell deficiency proved by specific clinical features and impression cytology
Exclusion criteria
* Age under 18 * Active ocular infection, Severe dry eye, Uncontrolled glaucoma * Immunocompromised host * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular surface clinical and pathological status(signs of limbal deficiency and immunopathological markers)after the surgery | Three years |
Countries
Thailand
Outcome results
None listed