Depression, Depressive Symptoms, Epilepsy, Seizure Disorder
Conditions
Keywords
Epilepsy, Seizure, Cognitive Behavioral Therapy, Mindfulness, Depression, Depressive symptoms, prevention, Coping skills, Quality of life, Telehealth, Phone intervention, Internet-based intervention
Brief summary
Project UPLIFT, a home-based treatment for depression in people with epilepsy, was designed to be delivered to groups by telephone or Web. The Project UPLIFT intervention materials were demonstrated to be effective in treating depression among people with epilepsy in Georgia. This project will assess whether the materials are also effective for preventing depression among people with epilepsy, and will extend the project beyond Georgia to Michigan, Texas, and Washington.
Detailed description
The study is a pilot test of Project UPLIFT for depression prevention during which the acceptability and estimates of effectiveness of the intervention, presented in the Web and telephone modes, are assessed.
Interventions
BEHAVIORALProject UPLIFT
Developed for home-based treatment of depression in people with epilepsy, Project UPLIFT is based upon Mindfulness-based Cognitive Therapy for depression. It includes 8 modules, group-delivered by either telephone or Web. Trainees and people with epilepsy co-facilitate the groups, supervised by a licensed mental health professional.The co-facilitators are trained and supervised by the Principal Investigator, a Georgia-licensed clinical psychologist and Associate Professor of Behavioral Science and of Epidemiology in public health. Activities are designed to increase knowledge about depression; monitoring, challenging, and changing thoughts; coping and relaxing; attention and mindfulness; focusing on pleasure; the importance of reinforcement, and preventing relapse.
Sponsors
University of Michigan
University of Washington
The University of Texas Health Science Center, Houston
National Institute on Minority Health and Health Disparities (NIMHD)
Emory University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of epilepsy * at least three months post initial diagnosis of epilepsy and either on medication or permission of the physician * symptoms of depression, but absence of moderate-to-severe depression, (8 \< CES-D \< 27) * 21 years of age and older * English speaking * had access to a telephone * mentally stable, as determined by a score of \> 26 on the Telephone Mini-Mental Status Exam (T-MMSE) * willing to participate * willing to complete assessments three times
Exclusion criteria
* no diagnosis of epilepsy * less than 3 months since diagnosis of epilepsy * no depressive symptom (CES-D \<8) * severe depression (CES-D \> 27) * suicidal ideation * previous participation in Project UPLIFT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Depressive Symptoms | Baseline (at 0 week) , Interim (at 8 weeks), Follow-up (at16 weeks) | Changes in depressive symptoms are measured using the modified Beck Depression Inventory (mBDI). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in seizure severity | Baseline (0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | Changes in seizure severity measured using the Liverpool Seizure Severity. |
| Changes in Depression and Mindfulness Knowledge and Skills | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | The changes are measured using an internally consistent scale assessing knowledge and skills associated with depression and mindfulness. The scale includes 18 true-false items assessing knowledge of depression based on the content of the UPLIFT modules. The scale also includes 13 Likert-scale assessing mindfulness skills based on the content of the UPLIFT modules. |
| Changes in Depressive Symptoms | baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | Changes in depressive symptoms are measured using the Beck Depression Inventory (BDI). |
| Change in Seizure Activity | Baseline (0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | Change measured using self-reported number of seizures in the past 4 weeks. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Changes in Satisfaction with Life | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | Changes are measured using the Satisfaction with Life Scale (Denier, E., et al., The satisfaction with life scale. Journal of Personality Assessment, 1985) |
| Changes in Sleep Quality | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | The study uses the Pittsburgh Sleep Quality Index to assess changes in sleep quality. |
| Changes in Depression Coping Self-Efficacy | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | The study uses Perraud, S., Development of the Depression Coping Self-Efficacy Scale (DCSES). Archives of Psychiatric Nursing, 2000 to assess changes in depression coping self-efficacy. |
| Changes in Self Compassion | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | The study uses Neff, K.D. and R. Vonk, Self-compassion versus global self-esteem: two different ways of relating to oneself. J Pers, 2009. 77(1): p. 23-50.. to assess changes in self compassion. |
| Changes in Physical and Mental Health Quality of Life | Baseline (at 0 week), Interim (at 8 weeks), Follow-up (at 16 weeks) | The study uses the Centers for Disease Control's Behavioral Risk Factors Surveillance System (BRFSS) questionnaire to assess changes in physical and mental health quality of life. |
Countries
United States
Outcome results
None listed