Exercise
Conditions
Keywords
Performance, Aerobic Exercise
Brief summary
Objectives: 1) Determine the effect of 4-weeks of high intensity interval training (HIIT) and free acid form β-Hydroxy-β-methylbutyrate (HMB-FA) on VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy in a population of endurance trained individuals. 2) Determine the effect of 4-weeks of HIIT and HMB-FA on changes in skeletal muscle physiological cross-sectional area (PCSA=Volume/Fascicle length) and muscle quality (MQ=echo intensity) in the rectus femoris and vastus lateralis. Subjects: Fifty males and females between the ages of 18 - 35 will be recruited to participate in this study. Subject will be randomized to one of three groups: a control group (CTL), an HIIT only group (HIIT) or a group which will take the amino acid metabolite HMB and perform HIIT (HMB-HIIT). Individuals assigned to CTL will undergo baseline testing. They will then be asked to continue their normal exercise routine for 4 weeks and will undergo post-testing after this time period. Study Protocol: Two testing sessions, on nonconsecutive days, will occur at least 72 hours prior to the start of the training period. The same testing protocols will be repeated at the end of the 4-week training period. Testing protocols include performance testing (VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy) and anthropometric measures (physiological cross-sectional area and muscle quality). The training protocol for individuals in the experimental groups will consist of 4-weeks of high intensity interval training with three sessions per week on an electronically braked cycle ergometer. Individual work -loads will be calculated based on the outcomes from each participant's preliminary testing.
Interventions
Sponsors
Metabolic Technologies Inc.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Recreationally-trained individuals with a VO2peak\>40 ml∙kg-1∙min-1. * Free of any physical limitations as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q * Between the ages of 18 and 35
Exclusion criteria
* Inability to perform physical exercise, as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q * Any chronic illness that causes continuous medical care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VO2peak/Ventilatory Threshold/fatigue threshold | Change from baseline after four weeks of high intensity interval training | A continuous graded exercise test will be performed on an electronically-braked cycle ergometer to determine maximal oxygen consumption (VO2peak) and the peak power output (PPO) in watts (W) at VO2peak. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EMG Activity Assessment | Change from baseline after four weeks of high intensity interval training | To assess EMG activity, a bipolar surface electrode arrangement will be placed over the muscles of the quadriceps. The EMG signals will be expressed as root mean square (RMS) amplitude values. During the leg extensor trial, electromyography (EMG) root mean square (RMS) amplitude values will be recorded |
Other
| Measure | Time frame | Description |
|---|---|---|
| Ultrasonography | Change from baseline after four weeks of high intensity interval training | Skeletal muscle images will be collected of the thigh muscles. These images will provide an ability to rate the quality of the leg muscles and determine the physiological cross-sectional area of the muscle |
| Three-minute Critical Power test | Change from baseline four weeks of high intensity interval training | The participant will have 60 seconds of unloaded cycling at 90 rpm, followed by an all-out three-minute effort with resistance being set as a function of pedaling rate. |
| Maximal Isometric Strength | Change from baseline after four weeks of high intensity interval training | To obtain the maximum isometric strength (kilograms) participants will be positioned in a BioDex S4 isometric dynamometer in a seated position. The participants will then be instructed to exert their maximum strength when trying to extend the knee and to produce the strength as fast as possible. |
Countries
United States
Outcome results
None listed