Effect of Physical Training Combined Cardiac Resynchronization Therapy in Heart Failure Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01939795

Enrollment

Registered

2013-09-11

Start date

2009-01-31

Completion date

2015-03-31

Last updated

2016-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

cardiac resynchronization therapy (CRT)

Brief summary

The investigators hypothesis that exercise training would potentiate the effects of cardiac resynchronization therapy in heart failure patients.

Interventions

OTHERexercise training and/or CRT

Three 40-minute exercise sessions per week on a treadmill for four months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* QRS\> 150 ms or 120-150ms associated dyssynchrony * The etiology can be idiopathic, ischemic, hypertensive and Chagas' disease * Ejection fraction \<35% * The optimal pharmacological treatment for heart failure

Design outcomes

Primary

Measure	Time frame	Description
Sympathetic nerve activity	4 months	Sympathetic nerve activity will be assessed by microneurography

Secondary

Measure	Time frame	Description
Peak oxygen consumption	4 months	Peak oxygen consumption will be determined by cardiopulmonary exercise testing
Quality of life	4 months	Quality of life will be assessed by questionnaire
Blood inflammatory markers	4 months	Blood inflammatory markers will be assessed by venipuncture
skeletal muscle strength	4 months	Muscular evaluation will be done muscle gene expression
Muscle Blood Flow	4 months	Forearm blood flow will be assessed by venous occlusion plethysmography

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026