Hypertension, Metabolic Syndrome
Conditions
Brief summary
At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness. This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.
Interventions
DRUGAtenolol
Crossover (atenolol 25-50 mg, bisoprolol 2.5-5 mg)
DRUGBisoprolol
Sponsors
Hospital Italiano de Buenos Aires
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hypertension * Metabolic syndrome
Exclusion criteria
* Severe hypertension \>180/110 * Secondary hypertension * Contraindication for betablockers * Prior treatment with betablockers (up to one month before inclusion) * History of neoplastic disease * Patients that do not sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| central blood pressure | two months |
Secondary
| Measure | Time frame |
|---|---|
| peripheral resistance | two months |
| cardiac index | two months |
| pulse wave velocity | two months |
Countries
Argentina
Outcome results
None listed