Cardiovascular Disease
Conditions
Keywords
moderate risk, high risk
Brief summary
Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control. Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.
Interventions
PROCEDUREExercise training with supervised sessions
Sponsors
University Hospital Center of Martinique
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* patients aged 50-69 years, with moderate or high cardiovascular risk
Exclusion criteria
* any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse wave velocity | With or without the exercise training |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability | within 12 weeks after exercise training |
Countries
Guadeloupe, Martinique
Contacts
Primary ContactArmelle JEAN-ETIENNE, MD
Outcome results
None listed