HER2-negative Breast Cancer, Inflammatory Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
Conditions
Brief summary
This phase I/II trial studies the side effects and best dose of romidepsin when given together with paclitaxel albumin-stabilized nanoparticle formulation and to see how well they work in treating patients with metastatic inflammatory breast cancer. Romidepsin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving romidepsin and paclitaxel albumin-stabilized nanoparticle formulation may be an effective treatment for inflammatory breast cancer.
Detailed description
PRIMARY OBJECTIVES: 1. To assess the safety of the combination of romidepsin plus Abraxane (paclitaxel albumin-stabilized nanoparticle formulation) delivered weekly. (Phase I) 2. To determine the maximum tolerated dose (MTD) of romidepsin with full dose weekly Abraxane to define a recommended phase II doses of the combination. (Phase I) 3. To assess the progression-free survival (PFS) in patients with human epidermal growth factor receptor 2 (HER2) negative, newly diagnosed metastatic inflammatory breast cancer treated with the combination of romidepsin and Abraxane. (Phase II) SECONDARY OBJECTIVES: 1. To assess the safety and tolerability of the combination of romidepsin and Abraxane. 2. To determine the adverse event profile of the combination of romidepsin and Abraxane. 3. To assess the overall response rate (ORR) and clinical benefit rate (CBR) in patients with newly recurrent inflammatory breast cancer (IBC) treated with the combination of romidepsin and Abraxane. OUTLINE: This is a phase I, dose-escalation study of romidepsin followed by a phase II study. Patients receive paclitaxel albumin-stabilized nanoparticle formulation intravenously (IV) over 30 minutes and romidepsin IV over 60 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 2 years, and then annually thereafter.
Interventions
DRUGRomidepsin
DRUGAbraxane
Sponsors
Celgene Corporation
Sidney Kimmel Cancer Center at Thomas Jefferson University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients must have histologically or cytologically confirmed breast carcinoma with a clinical diagnosis of IBC based on the presence of inflammatory changes in the involved breast, such as diffuse erythema and edema (peau d'orange), with or without an underlying palpable mass involving the majority of the skin of the breast. Pathological evidence of dermal lymphatic invasion should be noted but is not required for diagnosis. 2. Patients may have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension in accordance with RECIST criteria v. 1.1 as described in detail in section 11.0 or non-measurable tumors 3. Patients must have demonstrated metastatic disease and not received \>2 lines of systemic therapy for metastatic disease 4. Age \> 18 years 5. ECOG performance status 0, 1 or 2 6. Patients must have normal organ and marrow function as defined below: a) Leukocytes \> 2,500/mcL b) Absolute neutrophil count \> 1,500/mcL c) Hemoglobin \> 9 g/dl d) Platelets \> 100,000/mcL e) Total bilirubin \< 1.5 mg/dl f) AST/ALT (SGOT/SGPT) \< 2.5 x ULN g) Alkaline Phosphatase \< 2.5 x ULN (unless bone metastasis is present in the absence of liver metastasis, in which case 3.0 x ULN would be acceptable. h) Serum magnesium \> 1.8 mg/dL i) Serum creatinine \< 1.5 mg/dl j) Serum potassium \> 3.8 mmol/L 7. Tumor negative for HER2 expression (0 or 1+ by IHC) or negative FISH testing 8. Patients must have a life expectancy of at least 12 weeks 9. Patients must be recovered from the effects of any prior surgery, radiotherapy, or other antineoplastic therapy 10. Patients must have \< Grade 2 pre-existing peripheral neuropathy per CTCAE 11. Women of childbearing potential and sexually active males must use an effective contraception method during treatment and for three months after completing treatment 12. Negative serum or urine β-hCG pregnancy test at screening, performed no more than 72 hours prior to treatment initiation; for patients of childbearing potential 13. Ability to understand and willingness to sign a written informed consent and HIPAA consent document
Exclusion criteria
1. Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse event from agents administered more than 4 weeks earlier 2. Patients may not be receiving any other investigational agents or active anti-neoplastic therapies 3. Patients who have previously received romidepsin or Abraxane 4. Patients with untreated or uncontrolled brain metastases or leptomeningeal disease 5. Patients with known hypersensitivity to any of the components of romidepsin or who have had hypersensitivity reactions to paclitaxel 6. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements 7. Any known cardiac abnormalities such as: 1. Congenital long QT syndrome 2. QTc interval ≥ 500 milliseconds 3. Myocardial infarction within 6 months of C1D1. Subjects with a history of myocardial infarction between 6 and 12 months prior to C1D1 who are asymptomatic and have had a negative cardiac risk assessment (treadmill stress test, nuclear medicine stress test, or stress echocardiogram) since the event may participate 4. Other significant EKG abnormalities including 2nd degree atrio-ventricular (AV) block type II, 3rd degree AV block, or bradycardia (ventricular rate less than 50 beats/min) 5. Symptomatic coronary artery disease (CAD), e.g., angina Canadian Class II-IV (see Appendix III) In any patient in whom there is doubt, the patient should have a stress imaging study and, if abnormal, angiography to define whether or not CAD is present 6. An EKG recorded at screening showing evidence of cardiac ischemia (ST depression depression of ≥2 mm, measured from isoelectric line to the ST segment). If in any doubt, the patient should have a stress imaging study and, if abnormal, angiography to define whether or not CAD is present 7. Congestive heart failure (CHF) that meets New York Heart Association (NYHA) Class II to IV definitions (see Appendix IV) and/or known ejection fraction \<40% by MUGA or \<50% by echocardiogram and/orMRI 8. A known history of sustained ventricular tachycardia (VT), ventricular fibrillation (VF), Torsade de Pointes, or cardiac arrest unless currently addressed with an automatic implantable cardioverter defibrillator (AICD) 9. Hypertrophic cardiomegaly or restrictive cardiomyopathy from prior treatment or other causes 10. Uncontrolled hypertension, i.e., blood pressure (BP) of ≥ 160/95; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria 11. Any cardiac arrhythmia requiring an anti-arrhythmic medication (excluding stable doses of beta-blockers) 12. Patients taking drugs leading to significant QT prolongation (See Appendix I: Medications That May Cause QTc Prolongation) 13. Concomitant use of CYP3A4 inhibitors (see Appendix II) 8. Patients with known HIV, hepatitis B or C (However, if patients have previously been treated for hepatitis B or C and have undetectable viral loads, they can be considered eligible for trial) 9. Pregnant or breast feeding. Refer to section 4.4 for further detail 10. Patients with any other medical or psychological condition deemed by the investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum-Tolerated Dose of Romidepsin (Phase I) | 28 days | Determined according to incidence of dose-limiting toxicity, graded using the National Cancer Institute (NCI) CTCAE version 4.0 |
| Progression-Free Survival (PFS) | The duration of time from start of treatment to time of progression or death, whichever occurs first, assessed up to 5 years | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Adverse Events, Graded According to NCI CTCAE Version 4.0 | Up to 30 days | Summary tables of grade 2, 3, and 4 toxicities, adverse events (AE), and serious adverse events (SAE) will be generated at the conclusion of the study as well as at the conclusion of phase I study and after 15 patients have been collected on at the interim evaluation time point of the phase 2 part of the study. |
| Overall Response Rate (ORR) | Up to 5 years | The 95% confidence intervals should be provided. |
| Clinical Benefit Rate (CBR) | Up to 5 years | The 95% confidence intervals should be provided. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Treatment (Romidepsin and Abraxane) Patients receive abraxane IV over 30 minutes and romidepsin IV over 60 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Romidepsin
Abraxane | 9 |
| Total | 9 |
Baseline characteristics
| Characteristic | Treatment (Romidepsin and Abraxane) |
|---|---|
| Age, Continuous | 51.6 Years STANDARD_DEVIATION 9.33 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 0 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 9 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 9 Participants |
| Region of Enrollment United States | 9 Participants |
| Sex: Female, Male Female | 9 Participants |
| Sex: Female, Male Male | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 7 / 9 |
| serious Total, serious adverse events | 2 / 7 |
Outcome results
Primary
Maximum-Tolerated Dose of Romidepsin (Phase I)
Determined according to incidence of dose-limiting toxicity, graded using the National Cancer Institute (NCI) CTCAE version 4.0
Time frame: 28 days
Population: Data were not collected and the Outcome will never be analyzed.
Primary
Progression-Free Survival (PFS)
Time frame: The duration of time from start of treatment to time of progression or death, whichever occurs first, assessed up to 5 years
Population: Data were not collected and the Outcome will never be analyzed
Secondary
Clinical Benefit Rate (CBR)
The 95% confidence intervals should be provided.
Time frame: Up to 5 years
Population: Data were not collected and the Outcome will never be analyzed.
Secondary
Incidence of Adverse Events, Graded According to NCI CTCAE Version 4.0
Summary tables of grade 2, 3, and 4 toxicities, adverse events (AE), and serious adverse events (SAE) will be generated at the conclusion of the study as well as at the conclusion of phase I study and after 15 patients have been collected on at the interim evaluation time point of the phase 2 part of the study.
Time frame: Up to 30 days
Population: Data were not collected and the Outcome will never be analyzed.
Secondary
Overall Response Rate (ORR)
The 95% confidence intervals should be provided.
Time frame: Up to 5 years
Population: Data were not collected and the Outcome will never be analyzed.