Helicobacter Eradication
Conditions
Brief summary
Prospective study : Helicobacter pylori eradication therapy in accordance with past antibiotics use.
Detailed description
Antibiotics resistant is serious problem in helicobacter pylori eradication. Clarithromycin is very important antibiotics in eradication. But clarithromycin resistance is increased. Major cause of clarithromycin resistance is past consumption of macrolide. Thus the investigators propose eradication of macrolide used group bismuth contained four drugs therapy.
Interventions
DRUGHelicobacter pylori eradication
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Peptic ulcer disease * Gastric MALT lymphoma * Early gastric cancer * Familial history of gastric cancer * Idiopathic iron deficiency * Chronic idiopathic thrombocytopenia * Atrophic gastritis * Helicobacter infected dyspepsia * Long term NSAIDs use
Exclusion criteria
* Pregnant * Previous proton pump inhibitor, antibiotics or anticoagulant use within 2 weeks * Previous stomach surgery * Severe ill patients (heart failure, hepatic failure, renal failure, hematologic disorder, severe psychologic or neurologic disorder) * Previous Helicobacter eradication * Allergy for Helicobacter eradication medicine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate of Helicobacter pylori | one month |
Countries
South Korea
Contacts
Primary ContactKi Myung Lee, M.D., Ph.D.
Backup ContactSun Gyo Lim, M.D.
Outcome results
None listed