Gastric Bypass Surgery, Obesity
Conditions
Keywords
Bariatric, Gastric Bypass, Gastric Banding,, Incretins, glucagon-like peptide-1(GLP-1), gastric inhibitory peptide (GIP)
Brief summary
Analyze the effect of meal pattern (meal number, frequency, and form) on satiety, gut peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric bypass surgery (GBP).
Detailed description
The main goal is to study the effect of meal number, size and texture on metabolism and incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a single meal will be served, on the second study day, three small isocaloric meals, with the order of the conditions randomly assigned. The total amount of calories and the overall nutrient composition will be equivalent between conditions. The meals will be either all solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or liquid test meals. Gastric emptying will be measured by the acetaminophen test.
Interventions
OTHERLiquid Meal
OTHERSolid Meal
Sponsors
National Institutes of Health (NIH)
St. Luke's-Roosevelt Hospital Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Severely obese patients undergoing gastric bypass surgery (GBP)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in glucose levels after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals. | 1 month before GBP , 12-15 months post GBP |
| Changes in diet induced thermogenesis after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals. | 1 month before GBP surgery, and 12-15 months post surgery |
| Changes in insulin levels after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals. | 1 month before GBP surgery, 12-15 months post surgery |
| Changes in gut peptides after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals. | 1 month before GBP Surgery, and 12-15 months post surgery |
| Changes in satiety after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals. | 1 month before GBP, 12-15 months post GBP |
Countries
United States
Outcome results
None listed