Prostate Cancer Recurrent, Stage III Prostate Carcinoma, Stage II Prostate Carcinoma
Conditions
Keywords
prostate cancer, MRI, PET
Brief summary
To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer * to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer * to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer
Detailed description
To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer * Recruiting 30 patients with prostate cancer ahead to radical prostatectomy * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions * establishing optimal imaging technique for prostate PET/MR To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer * comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy * outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer * Recruiting 15 patients with recurrent prostate cancer treated by surgery, hormone, or radiation therapy * Recruiting 15 patients with treated prostate cancer without recurrence * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18F-FDG in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * comparison of findings on PET/MR, MRI, and PET/CT with clinical data in two patient groups with or without recurrent prostate cancer * outcome assessment: accuracy of PET/MR for early detection and localization of recurrent prostate cancer compared with MRI only and PET/CT only
Interventions
DEVICEPET/MR
Multi-radiotracer PET/MR will be performed in patients with primary and recurrent prostate cancer
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
* patient with prostate cancer before treatment * patient with prostate cancer treated * patient with prostate cancer recurrent
Exclusion criteria
* patient with contraindication for MRI * Patient with severe renal impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| accuracy of PET/MR predicting localization and staging of prostate cancer | 1 week after radical prostatectomy | analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| accuracy of early detection and localization of recurrent prostate cancer | 1 week after PET/MR imaging | accuracy of PET/MR for early detection and localization of recurrence by comparison of PET/MR findings with clinical data in two groups of patients with or without recurrent prostate cancer |
Countries
South Korea
Contacts
Primary ContactJeong Yeon Cho, MD
Backup ContactSang Youn Kim, MD
Outcome results
None listed