Colorectal Cancer
Conditions
Brief summary
Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability. The investigators intend to characterize the changes of coagulation in colorectal cancer patients by using the point-of-care device after the infusion of magnesium sulphate.
Interventions
DRUGMagnesium Sulfate
DRUGNormal saline
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* The patients undergoing a laparoscopic colorectal cancer surgery
Exclusion criteria
* Renal disease * Hepatic disease * Neuromuscular disease * Coagulation disorder * Cardiopulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of MCF of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Alpha angle of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of MCF of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of CT of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of CFT of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Alpha angle of EXTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of maximum clot firmness (MCF) of FIBTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Clotting time (CT) of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Clot firmness time (CFT) of INTEM | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
Secondary
| Measure | Time frame |
|---|---|
| Change of Hemoglobin | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Platelet count | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of International normalized ratio of prothrombin time | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Fibrinogen | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
| Change of Activated partial thrombin time | 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day |
Countries
South Korea
Outcome results
None listed