Recurrence of HCC After LDLT
Conditions
Keywords
LDLT,HCC, Microvascular invasion
Brief summary
Within community with high incidence of HCC, stretching the limits could be justified based on tumor characters and its biological behavior
Detailed description
590 Egyptian patients underwent LDLT; of them, 172 (32%) patients were transplanted for HCC. Twenty six cases (15.1%) were excluded due to early postoperative mortality (n=22) or due to non HCC related mortality (n=4). One hundred forty six patients were retrospectively reviewed to determine prognostic factors for recurrence.
Interventions
None listed
Sponsors
Ain Shams University
Study design
Observational model
CASE_CROSSOVER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 62 Years
Healthy volunteers
No
Inclusion criteria
* Egyptien Patients with HCC * Patients within Milan Criteria * Patients beyond Milan criteria are selected on a case by case basis until 2005. From 2005 , patients beyond Milan criteria are subjected to down staging protocol and then reassessed (pre transplantation local ablative therapy either with RFA or TACE according to the size and the site of the lesion and we wait for 12 weeks after ablation ,only those with well ablated lesions, decreased AFP and no denovo lesions were transplanted).
Exclusion criteria
* • Evidence of macro vascular invasion by CT portography and/or US duplex. * Metastatic HCC * General contraindications for LT (ongoing sepsis, other major co morbidities,…). * Early postoperative mortality (first1 month). * Post transplant mortality during the period of follow up due to any cause other than recurrent HCC (e.g. sepsis, rejection, cardiological or cerebrovascular complications…)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence of Hepatocellular carcinoma after LDLT | at least 6 months |
Countries
Egypt
Outcome results
None listed