Abdominal Aortic Aneurysm, Cardiac Arrest, Sudden Cardiac Death, Coronary Heart Disease NOS, Heart Failure, Intracerebral Haemorrhage, Ischemic Stroke, Myocardial Infarction, Peripheral Arterial Disease, Stable Angina Pectoris, Stroke, Subarachnoid Haemorrhage, Transient Ischemic Attack, Unheralded Corronary Death, Unstable Angina
Conditions
Brief summary
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
Detailed description
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Interventions
OTHERNo treatment
Sponsors
Wellcome Trust
National Institute for Health Research, United Kingdom
University College, London
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* One year prior to study entry (up-to-standard follow-up, CPRD quality research standard). * 30 years or older * Recorded sex * Free of symptomatic CVD at inclusion.
Exclusion criteria
* Pregnant women in the 6 months before the eligibility date
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases. | Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years | Associations studied: * overall * by sex * by age group * in high risk groups (smokers, hypertensive disease, obese, diabetic, depression) * before and after the introduction of the Quality and Outcomes Framework in England |
Secondary
| Measure | Time frame |
|---|---|
| Lifetime cumulative incidence per quintile of social deprivation | Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years |
Other
| Measure | Time frame |
|---|---|
| Heterogeneity in associations across 12 cardiovascular diseases using the Tau-squared statistic and I-square statistics. | Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years |
Countries
United Kingdom
Outcome results
None listed