Effects of Intensive Statin Treatment on Left Ventricular Function

Effects of Intensive Statin Therapy on Left Ventricular Function for Patients With the First Acute Anterior Myocardial Infarction After Directly to Percutaneous Coronary Intervention.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01936103

Enrollment

120

Registered

2013-09-05

Start date

2012-04-30

Completion date

2014-07-31

Last updated

2013-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Anterior Myocardial Infarction

Keywords

Acute anterior myocardial infarction, Percutaneous coronary stent implantation, Intensive statin therapy, Left ventricular function

Brief summary

First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left ventricular function , reduce major adverse cardiovascular events .

Interventions

DRUGstandard group

standard statin treatment:Atorvastatin statins 20mg / night .

DRUGintensive group

intensive statin treatment： Admission atorvastatin statins the 80mg, after surgery，atorvastatin 40mg / night，and until 30 days after the operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. ≥ 18 years of age 2. the first time clinical diagnosis of acute anterior myocardial infarction , the time of onset ≤ 12 hours ,intends underwent emergency PCI 3. informed consent

Exclusion criteria

1. Taking , or the need for long-term use of statins is greater than the initial dose 2. treated with PCI again within a mouth 3. active liver disease or liver dysfunction 4. the diagnosis of myopathy 5. severe renal insufficiency ( serum creatinine \> 178umol / L ) 6. Statin drug allergy or had a serious adverse reaction 7. severe aortic stenosis or mitral stenosis , hypertrophic obstructive cardiomyopathy , pericardial disease 8. pregnancy 9. malignancy or any other end-stage diseases result in a life expectancy of \< 6 months 10. be participating in other clinical studies 11. not suitable for inclusion of the other cases 12. not treated with PCI

Design outcomes

Primary

Measure	Time frame	Description
left ventricular function	30 days	ultrasonic observation of left ventricular end-diastolic diameter

Secondary

Measure	Time frame
the left ventricular function	6 months
plasma brain natriuretic peptide	30days

Other

Measure	Time frame	Description
Aspartate aminotransferase (AST)	1 year	Aspartate aminotransferase (AST) returned to normal in the perioperative period
alanine aminotransferase (ALT)	1 year	alanine aminotransferase (ALT)returned to normal in the perioperative period
enzymes	1 year	the level of CK peak
Major adverse cardiac and cerebral events at 1 year	1 year	1 year after death, cardiac death , myocardial infarction , heart failure , cardiac causes hospitalization , revascularization combined endpoint of cerebrovascular events .

Countries

China

Contacts

Primary ContactGeng Wang, Dr

Wanggeng69@hotmail.com+86-24-28897280

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026