Coagulation; Intravascular
Conditions
Keywords
Continuous heparin infusion, Intermittent heparin infusion, during catheter ablation
Brief summary
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.
Detailed description
Intravenous heparin was used during the procedure to prevent catheter-induced thrombosis. heparin is administered during the procedure to achieve recommended activation clotting times (ACT) values, typically \>300 seconds to prevent thromboemboli during the procedure. Most of the practitioners was that ACT level should be checked at 30- to 60-minute intervals and then have injected intermittently. intermittent heparin infusion, concentration is great changed because the heparin has 30minutes half-period. researchers postulate that a constant therapeutic concentrations would be beneficial to continuous infusion than intermittent infusion.
Interventions
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Sponsors
Study design
Eligibility
Inclusion criteria
* Atrial Fibrillation, Radiofrequency catheter ablation scheduled
Exclusion criteria
* Clinical trial denied
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| therapeutic ACT retention rate during procedure | 2 years |
Countries
South Korea