Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients

Common Canister Protocol for Metered Dose Inhaler Administration in Mechanically Ventilated Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01935388

Enrollment

354

Registered

2013-09-05

Start date

2013-06-30

Completion date

2016-03-31

Last updated

2016-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia

Keywords

Mechanical ventilation, chronic obstructive pulmonary disease, asthma, common canister, MDI, ventilator associated pneumonia

Brief summary

Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one patient. Small reports suggest that this method does not pose an increased infectious risk and is associated with significant cost savings. Common canister protocols offer a solution to the discordance between inhaler sizes and average inpatient use of the drugs. Metered dose inhaler canisters are contain enough drug for several days to weeks of daily use. However, the average length of stay for most inpatients is only several days. Therefore, most inpatients do not use all of the canister contents, an unused resource that is potentially wasted. The common canister approach has not been previously described in mechanically ventilated patients (people requiring intensive care unit admission on breathing machines). This study aims to assess the safety of common canister utilization by assessment and comparison of infection rates in the study and control group.

Interventions

OTHERCommon canister

Drug administration via a shared canister with a standardized cleaning protocol.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* mechanically ventilated patients prescribed bronchodilator therapy in a medical intensive care unit

Exclusion criteria

* lung transplant * neutropenic * contact isolation

Design outcomes

Primary

Measure	Time frame	Description
Ventilator-associated pneumonia (VAP)	48 hours after intubation	Pneumonia that developed in association with mechanical ventilation

Secondary

Measure	Time frame	Description
Inhaler drug cost	During period of mechanical ventilation, which varies depending on patient's severity of illness and reason for intubation; on average may range from 3-5 days.	Inhaler charges accrued during mechanical ventilation

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026