Mild Cognitive Impairment
Conditions
Keywords
mild cognitive impairment, seniors, cognitive training, driving, driving simulation, intervention, goal management training, process speed training
Brief summary
The objective of this study is to assess the effectiveness of an intervention to address both executive function and processing speed changes that contribute to poor driving performance in adults with Mild Cognitive Impairment (MCI). Our hypotheses are that the study intervention will improve performance on a driving simulator and will improve (i) executive function, specifically attention and planning, (ii) useful field of view, (iii) mood, (iv) quality of life, and (v) reported motor vehicle crashes and driving infractions.
Detailed description
Executive function and processing speed are recognized critical correlates of driving performance and have been shown to decline in older adults and in persons with mild cognitive impairment. Members of our research team have shown that group executive function training such as Goal Management Training results in benefits for healthy older adults, including improved simulated daily activities. The ultimate purpose of our research is to develop interventions to help maintain older adults' mobility in order to assist their 'aging at home'. The planned study will assess the effectiveness of an intervention that includes Goal Management Training + processing speed training (using DriveSharp software), which is designed to address both executive function and processing speed changes that contribute to poor driving performance in people with diagnosed mild cognitive impairment. The investigators will measure the effectiveness of the intervention on driving performance, sustained attention, divided attention, executive function, depressive symptoms and quality of life.
Interventions
BEHAVIORALGoal Management Training
9 weeks, 2 hour session/week, 1 hour/day homework (6 days/week), 2 x 0.5 hour sessions with trainer
BEHAVIORALProcessing Speed Training
9 weeks, a total of 10 hours of computer-based processing speed training; 60-75 minutes/week
BEHAVIORALBrain Health Workshop
9 weeks, 2 hour session/week, 1 hour/day homework (6 days/week), 2 x 0.5 hour sessions with trainer
Sponsors
Unity Health Toronto
Sunnybrook Health Sciences Centre
Lakehead University
McGill University
University Health Network, Toronto
Michael Garron Hospital
Centre for Addiction and Mental Health
Baycrest
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* mild cognitive impairment * currently driving or voluntarily stopped driving within the past year * fluent in English
Exclusion criteria
* visual problems that cannot be corrected with standard lenses * alcohol/substance abuse * stroke with residual motor /sensory deficit * traumatic brain injury * seizure in the past two years * Parkinson's disease * Multiple sclerosis * untreated sleep apnea * history of motion sickness * history of dizziness, vertigo * active primary psychiatric disorder requiring treatment * on a dose of cognitive enhancing medication for less than 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Driving Performance | 9-14 weeks | Measurements obtained on a computer-based driving simulation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Geriatric Depression Scale (GDS-15 item) | 9-14 weeks, 33-38 weeks | Depressive symptoms |
| Sustained Attention to Response Task (SART) | 9-14 weeks, 33-38 weeks | Sustained attention |
| D-KEFs Tower Test | 9-14 weeks, 33-38 weeks | Visuospatial planning |
| Dysexecutive Questionnaire | 9-14 weeks, 33-38 weeks | Absentmindedness, executive dysfunction in daily life |
| Cognitive Failures Questionnaire | 9-14 weeks, 33-38 weeks | Absentmindedness, executive dysfunction in daily life |
| Quality of Life: AD (QOL-AD) | 9-14 weeks, 33-38 weeks | Quality of life with MCI and Alzheimer's disease |
| Useful Field of View Test (UFOV) | 9-14 weeks, 33-38 weeks | Visual field of view |
Countries
Canada
Outcome results
None listed