Depression, Parkinson's Disease
Conditions
Keywords
Depression, Parkinson's disease, Cognitive-Behavioral Treatment
Brief summary
The purpose of this project is to develop and pilot-test a guided cognitive-behavioral self-help program for mild-to-moderate depression in Parkinson's disease (dPD). We will pilot-test the guided self-help treatment on 20 people with PD and their caregivers. The manual will be revised based on participant feedback. Several feasibility measures regarding the guided self-help program (i.e., recruitment, retention, enjoyment, helpfulness, adherence) will also be assessed. Moreover, preliminary estimates of effect size for this guided self-help program will be calculated and used in future research. We hypothesize that people with PD will report decreases in depression, anxiety, and negative thoughts and improvements in quality life and sleep and that caregivers will report decreases in burden after participating in the guided self-help program
Detailed description
To our knowledge, Cognitive-Behavioral self-help interventions remain unexplored for depression in PD to date. The results of this study will be used to support future treatment development efforts for depression and other psychiatric complications in PD that may improve the access to and quality of mental health care in this medical population.
Interventions
BEHAVIORALGuided Cognitive-Behavioral Self-Help
Participants will complete the study treatment at home. Bi-weekly telephone support will be provided by study staff.
Sponsors
Rutgers, The State University of New Jersey
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Previous diagnosis of Parkinson's disease by a general neurologist or Movement Disorders Specialist 2. Clinically significant depression as determined by study staff 3. 35-85 years old 4. Stable medication regimen ≥ 6 weeks 5. No change in mental health treatment in past 2 months \_
Exclusion criteria
1. Severe depressive symptoms 2. Suicidal plans or intent 3. Significant cognitive impairment 4. Significant motor fluctuations (i.e., ≥ 50% of the day) 5. Unstable medical conditions 6. Receiving CBT elsewhere
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Hamilton Depression Rating Scale | 14 weeks | A clinician-administered rating scale for depression |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hamilton Anxiety Rating Scale | 14 weeks | A clinician-administered rating scale of anxiety |
| Inference Questionnaire | 14 weeks | Self-report measure of negative thoughts |
| Caregiver Distress Scale | 14 weeks | Self-report measure of caregiver stress |
| Beck Depression Inventory | 14 weeks | A self-report measure of depression |
| Medical Outcomes Short Form | 14 weeks | Self-report quality of life scale |
| Feasibility and adherence measures | 10 weeks | Feasibility \[Likert ratings (0-10) on the dimensions of readability, clarity, effort, enjoyment, fatigue, helpfulness, and progress regarding treatment materials\] and adherence measures \[a numerical rating regarding the % of recommended activities accomplished\] |
| Clinical Global Impression-Improvement Scale | 14 weeks | Clinician-rated scale of depression improvement |
| Insomnia Severity Index | 14 weeks | Self-report sleep scale |
Countries
United States
Outcome results
None listed