Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Conditions
Keywords
Coronary stenosis, Angina pectoris, Left ventricular wall motion abnormalities, 2D-Strain
Brief summary
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
Detailed description
Each patient with typical angina pectoris symptoms will get echocardiographic examination during the inclusion phase. If motion disorder of regional left ventricular myocardial wall is detected, patient will get coronary angiography (not study related, caused of typical angina pectoris symptoms and high probability of CHD). If coronary stenosis related to motion disorder is available, patient will be randomized in two groups during coronary angiography. * First Group: Patient will get echocardiographic examination during coronary angiography. 2D-Strain Analysis will be performed based on data of this echocardiographic examination. Only when vitality in the contraction impaired segments will be established based on 2D-Strain Analysis, PCI (Percutaneous Coronary Intervention) will be performed. * Second Group: Coronary angiography by patient will be canceled. Patients will get viability assessment using MRI(Magnetic resonance imaging) within the next 7 days. When vitality will be established with MRI, patient will get PCI (Percutaneous Coronary Intervention). In addition, as part of a feasibility analysis, the possibility of a consolidation of data of coronary angiography with the ultrasound images will be researched by first group of patients. The aim is to simplify the visualization of the intraprocedural vitality detection. For this purpose, a position sensor based on electromagnetic fields (EMT) will be used during coronary angiography.
Interventions
DEVICECardiac ultrasound
Patient will get echocardiographic examination during coronary angiography. 2D-Strain Analysis will be performed based on data of these echocardiographic examination. Only when vitality in the contraction impaired segments will be established based on 2D-Strain Analysis, PCI will be performed.
DEVICEMRI scanner
Coronary angiography on patient will be canceled. Patients will get viability assessment using MRI within the next 7 days. When vitality will be established with MRI, patient will get PCI.
Sponsors
RWTH Aachen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Typical angina pectoris symptoms * Echocardiographic determination of regional motion disfunction of left ventricular wall * Establishment of needly treatment of stenosis related to motion disorder based on coronar angiography. * Feasibility of MRI-Examination. * Patients which are legally competent and which are mentally able to understand the study staff * Patients give their written consent
Exclusion criteria
* Allergy against contrast agent * Patients with limited renal function(GFR \< 60 ml/min) * Acute or instable angina pectoris
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| State of health score | 6 month after diagnistics | State of health score will be determinated by all patients for the evaluation of clinical outcomes (using the standardized questionnaire on state of health (SF-36))6 months after clinical diagnostics. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular function (ejection function) | 6 month after diagnistics | Left ventricular function (ejection function) by all patients will be determinated 6 month after diagnostics. |
| End-diastolic and end-systolic volume. | 6 month after diagnostics | End-diastolic and end-systolic volume will be determined by all patients 6 month after diagnostics |
| Capture of Major Adverse Cardiac and Cerebrovascular Events(MACCE) | 18 month after diagnostics | It will be determined, whether all patients suffered any major adverse cardiac and cerebrovascular events (MACCE) inter alia stroke, myocardial infarction, death 18 month after diagnostics |
Countries
Germany
Outcome results
None listed