Drug Usage
Conditions
Keywords
LMA removal, remifentanil, propofol
Brief summary
The investigators attempted to determine the optimal effect-site concentration of remifentanil for smooth removal of the LMA from propofol anesthesia.
Detailed description
At the end of the surgery, propofol infusion was stopped and remifentanil was titrated to predetermined (initial concentration 1.0 ng/ml for the first patient). LMA removal was performed when the patients opened their eyes and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed.
Interventions
DRUGremifentanil
The concentration of remifentanil was determined by modified Dixon's up-and-down method, starting from 1.0 ng/ml (0.2 ng/ml as a step size)
LMA was removed when the patients opened their eyes, and spontaneous respiration and adequate tidal volume and ventilatory frequency were confirmed
Sponsors
Ajou University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II patients undergoing general anesthesia for short elective surgery (\<1 hr)
Exclusion criteria
* G-E reflux * obesity (BMI\>30) * anticipated difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| smooth removal of LMA | from end of surgery to removal of LMA (participants will be followed for the emergence periods, an expected average of 15 min). | the response of patients to the removal of LMA (classified as either 'success \[smooth emergence\]' or 'failure') during infusion of remifentanil. |
Countries
South Korea
Outcome results
None listed