Gastric Banding, Gastric Bypass Surgery, Type 2 Diabetes
Conditions
Keywords
Bariatric, Gastric Bypass, Gastric Banding,, Type 2 Diabetes, Incretins, GLP-1, GIP, Insulin secretion, insulin sensitivity
Brief summary
Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of cases. The mechanism and time course of these changes have not been well studied and are poorly understood. The primary aim of this study is to investigate the potential weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB subjects after similar weight loss.
Detailed description
All participants will be tested before and then after 10 and 20-30% weight loss after either GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition measurements.
Interventions
None listed
Sponsors
National Institutes of Health (NIH)
St. Luke's-Roosevelt Hospital Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* obese type 2 diabetes individuals scheduled to undergo bariatric surgery by either gastric banding or gastric bypass surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Incretin Effect | Before surgery, 1, 12, and 24 months post | Effect of GBP and AGB on incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Body Composition | Before surgery, 12, and 24 months post | Body composition measurements to determine body volume, size, and fat |
Countries
United States
Outcome results
None listed