Blood Transfusion
Conditions
Keywords
Heating transfusion
Brief summary
To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.
Detailed description
Hypothermia is an effective therapeutic intervention to reduce hypoxic ischemia brain injury in animal experiments and in clinics.In a recent study, it has been shown that perioperative warming was associated with a higher incidence of cognitive dysfunction in elderly patients.Therefore, we hypothesised that perioperative heating transfusion have a side effect on brain function of surgical patients.
Interventions
None listed
Sponsors
General Hospital of Ningxia Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* adult patients scheduled for major surgery under general anesthesia and they probably need a blood transfusion during the procedure.
Exclusion criteria
•Patients with a history of stroke, central nervous system disease , metabolic disturbance, psychiatric illness, hearing impairment, drug abuse or unwilling to participate in assessment \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain fuction during perioperative period | Change from baseline at post-transfusion 15min, 30min, 1hour, 2hour, 3 hour, 6hour, 12hour, 24hour | Brain function includes cerebral blood flow and cerebral oxygen saturation |
Secondary
| Measure | Time frame |
|---|---|
| the cognitive performance and the score of postoperative quality recovery scales ( PQRS) | Chang from baseline at 15min,40min,1day,3day and 7day postoperative lay |
Other
| Measure | Time frame |
|---|---|
| serum concentration of inflammatory cytokine | change from baseline at 3hour, 6hour, 12hour, 24hour after transfusion |
Countries
China
Outcome results
None listed