Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood

Effect of Sleep Deprivation on Expression of T Cell Markers in Peripheral Blood of Medical Residents

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01930279

Enrollment

Registered

2013-08-28

Start date

2013-09-30

Completion date

2014-09-30

Last updated

2013-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep Deprivation

Keywords

T cell markers

Brief summary

Sleep deprivation was found to affect many organs including the immune system and predisposing for various health consequences including diabetes hypertension infections and increase in neoplastic diseases. Subjects will be evaluated for immune parameters in peripheral blood test following a regular nigh sleep and compared with a test performed following a night shift in which they slept less than 3 hours. Each participant will serve as its own control.

Detailed description

Overall Study Design and Plan 1. Subjects will be bled on the day of the experiment between 8and 9 AM. 2. Blood tubes will be tested for T cell markers, serum cytokines levels, and other immune parameters by western blots. 3. The first tube will be tested on the day of experiment. 4. The second tube will kept in the lab and will be tested 24 hours later. 5. The third tube will be kept in the pocket of the subject and be tested 24 hours later. 6. The fourth tube will be kept in the pocket of another subject and will be tested 24 hours later. 7. The subject will be tested again following 24 hours. 8. Each subject will be tested twice following a regular 6-8 hours of sleep, and following an on call duty in which he slept less than 3 hours.

Interventions

OTHERBlood withdrawal

Blood withdrawal

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Male and female ages 18-40 signed confirmed consent no evidence of chronic disease or chronic medications

Exclusion criteria

Any type of acute infection or other acute illness

Design outcomes

Primary

Measure	Time frame
surface markers of T cell as assessed by FACS	6 months
serum cytokine levels	6 months
immune parameters to be assessed by western including STAT proteins	6 months

Countries

Israel

Contacts

Primary ContactAyman Abu rmeileh, MD

aymansar@gmail.com0584400010

Backup ContactTawfik Khoury, MD

taufick@hadassah.org.il0509870611

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026