Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial

Conditions

Colorectal Cancer Control and Prevention

Keywords

Prevention & control, Diet, Functional food, Nutrition Assessment, Oryza sativa, Rice Bran, Phaseolus vulgaris L., Legumes, Microbiome, Metabolomics, Prebiotics

Brief summary

The purpose of this study is to explore the effects of cooked navy bean powder or rice bran consumption on the stool microbiome and metabolome of colorectal cancer survivors and healthy adults.

Detailed description

Objectives: 1. To learn about how increased cooked navy bean powders or rice bran dietary intake affect the stool microbiota of colorectal cancer survivors and healthy adults. 2. To determine whether cooked navy bean powders or rice bran consumption modulate microbial metabolism. 3. To observe dietary changes in the blood, urine and stool metabolite profiles and inflammatory cytokines.

Annika Weber, Hend Ibrahim, Bridget A. Baxter, Robin Kumar, Akhilendra Kumar Maurya et al. (9 authors)

Cancers2023-04-1012 citations

10.3390/cancers15082231

Abstract CT138: Increasing dietary rice bran and navy bean intake for colorectal cancer control and prevention: A randomized-controlled pilot investigation

Erica C. Borresen, Renee C. Oppel, Dustin G. Brown, Regina J. Brown, Elizabeth P. Ryan

Cancer Research2017-07-01

10.1158/1538-7445.am2017-ct138

Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors.

Sheflin AM, Borresen EC, Kirkwood JS, Boot CM, Whitney AK, Lu S, Brown RJ, Broeckling CD, Ryan EP, Weir TL.

2016-09-1281 citations

10.1002/mnfr.201500905

Interventions

DIETARY_SUPPLEMENTPlacebo-Control Meals and Snacks

DIETARY_SUPPLEMENTCooked Navy Bean Powder Meals and Snacks

DIETARY_SUPPLEMENTRice Bran Meals and Snacks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* ≥ 18 years of age. * Be a Colorectal Cancer Survivor that is a minimum of 4 months post chemotherapy/radiation treatment. OR be a healthy adult with no prior history of treatment for cancer. * BMI between 25-35 * no previous or concurrent malignancy except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer and other cancer for which the patient has been disease free for five years. * Ability to complete questionnaire(s) and dietary food logs * Willingness to consume meals/snacks provided for 28 consecutive days * Drink less than or equal to one alcoholic drink/day

Exclusion criteria

* History of food allergies and/or major dietary restrictions * Pregnant or lactating or planning to become pregnant * Self identified as a smoker * Taking prescribed medication to control their lipids * Taking Bean-O, other anti-flatulence medications or prolonged antibiotic use (one month) * Have a history of gallstones.

Design outcomes

Primary

Measure	Time frame
Stool Microbiome Composition and Metabolome	5 years

Secondary

Measure	Time frame
Navy Bean or Rice Bran metabolites in stool, urine and blood.	5 years

Countries

United States

Outcome results

None listed