Agoraphobia, Panic Disorder
Conditions
Keywords
Panic Disorder, Agoraphobia, Physical Activity
Brief summary
Physical activity (treadmill) prior to in-vivo exposure supports the effect of cognitive behavioural therapy in patients with panic disorder and agoraphobia.
Detailed description
Patients receive a 12-session manualized cognitive behavioural therapy, implemented over 7 weeks and followed by two booster sessions. Five sessions consist of in-vivo exposures. Prior to these sessions patients undergo a training of physical activity. Half of the patients complete training on a treadmill at 70% of their maximal oxygen uptake while the other half complete training at 30%.
Interventions
BEHAVIORALCognitive Behavioural Therapy
12 sessions of CBT including psychoeducation, interoceptive exposure and in-vivo exposure
Sponsors
German Federal Ministry of Education and Research
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Subject familiarized with experimental procedure and had given written informed consent * Diagnosis of panic disorder with agoraphobia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) * Score \>= 18 in Hamilton Rating Scale for Anxiety * Score \>= 4 in Clinical Global Index * Reachability of patient for treatment and follow-up
Exclusion criteria
* DSM-IV Axis I diagnoses of any psychotic disorder, bipolar disorder, current alcohol or drug dependence and Axis II borderline personality disorder * Change in pharmacological treatment in the last 4 weeks * Acute suicidality * Medical contraindications for mild to moderate exercise training or exposure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hamilton Rating Scale for Anxiety (CIPS 1995) | Change from Baseline to 31 weeks (follow-up) | Global interviewer rated measure for anxiety and severity indicator of an anxiety disorder |
| Mobility Inventory (Chambless 1984) | Change from Baseline to 31 weeks (follow-up) | A 27-item inventory for the measurement of self-reported agoraphobic avoidance behavior |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anxiety Sensitivity Index (Taylor 1998) | Baseline, every second session, 3 weeks, 7 weeks, 31 weeks (follow up) | — |
| Body Sensations Questionnaire (Chambless 1984) | Baseline, 3 weeks, 7 weeks, 31 weeks (follow up) | — |
| Clinical Global Index (CIPS 1995) | Baseline, 3 weeks, 7 weeks, 31 weeks (follow up) | — |
| Panic and Agoraphobia Scale | Change from baseline to 31 weeks (follow-up) | Severity scale for panic disorder |
| Agoraphobic Cognitions Questionaire (Chambless 1984) | Baseline, 3 weeks, 7 weeks, 31 weeks (follow up) | — |
| Beck Depression Inventory (CIPS 1995) | Baseline, 3 weeks, 7 weeks, 31 weeks (follow up) | — |
Outcome results
None listed