Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01928212

Enrollment

500

Registered

2013-08-23

Start date

2013-08-31

Completion date

2014-05-31

Last updated

2014-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

retinal nerve fiber layer thickness, optical coherence tomography, Parkinson disease

Brief summary

Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness. A reduction of the RNFL thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, CADASIL and Alzheimer's disease. Different studies have reported RNFL changes also in Parkinson's disease (PD),a common neurodegenerative disease characterized by motor dysfunctions, originally described by James Parkinson in 1817. PD is characterized by selective dopaminergic neuronal cells loss, which may correlate with RNFL thinning. Previous studies on this subject, however, reported contradicting results. Some investigations reported reductions of the RNFL thickness while others did not. In the present study, in order to determine whether RNFL thickness is reduced in PD patients, we performed a meta-analysis and systematically evaluated RNFL thickness measurements with OCT in a series of PD patients and in the healthy control groups.

Interventions

DEVICEOptical coherence tomography

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. case-control studies; 2. patients with PD were compared with healthy controls; 3. all subjects underwent RNFL thickness measurement by OCT; 4. studies should provide the data of peripapillary RNFL thickness; 5. sample size ≥10 in each group.

Exclusion criteria

1. authors did not make RNFL measurements; 2. study without healthy control group; 3. the outcome values can not be used for meta-analysis; 4. duplicated articles.

Design outcomes

Primary

Measure	Time frame	Description
Retinal Nerve Fiber Layer Thickness	Baseline	Retinal nerve fiber layer thickness included average thickness (360° measurement), temporal quadrant thickness (316-45°), superior quadrant thickness (46-135°), nasal quadrant thickness (136-225°) and inferior quadrant thickness (226-315°)was measured by OCT.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 21, 2026