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The Effects of Consuming Whey Protein Polydextrose Snacks on Appetite and Energy Intake

The Effects of Consuming Between- Meal, High Protein Polydextrose Containing Snack Bars on Subjective Satiety, Energy Intake and Metabolic Responses.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01927926
Enrollment
10
Registered
2013-08-23
Start date
2008-05-31
Completion date
2008-10-31
Last updated
2013-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Energy intake, appetite, satiety, gut hormones

Brief summary

Developing functional foods that enhance satiety may be beneficial to individuals to help manage body weight. We have previously shown that consuming a mid-morning liquid preload with increasing proportion of energy derived from whey protein and addition of polydextrose reduced voluntary energy intake at a lunchtime meal compared to a liquid preload of the same energy content but lower in protein and containing no polydextrose. This study aims to investigate if these results can be replicated when the preload is in the form of a snack bar. We will also investigate whether the daily consumption of the snack bar has an effect on energy intake, subjective appetite and metabolic parameters compared to a control snack of the same energy but with a minimal protein content and without the addition of polydextrose. We hypothesize that the whey protein polydextrose snack will reduce voluntary energy intake at a subsequent test meal, suppress subjective appetite ratings compared with the control snack bar.

Detailed description

Background: Developing functional food products that enhance satiety, suppress appetite, and reduce subsequent voluntary food intake to a greater extent than a similar energy matched food product, may be useful to help consumers adhere to energy restricted diets and optimize successful body weight management. A range of foods and food constituents have been reported to have the potential to produce short term changes in appetite and energy intake. However, the effects of consuming foods containing such ingredients on appetite, energy intake over the longer term is unclear. We have previously shown that consuming a mid-morning liquid preload with increasing proportion of energy derived from whey protein and addition of polydextrose reduced voluntary energy intake at a lunchtime meal compared to a liquid preload of the same energy content but lower in protein and containing no polydextrose. Aims: This study aims to investigate if previous findings can be replicated using solid snack bars containing whey protein and polydextrose. We will also investigate whether the daily consumption of the snack bar has an effect on energy intake, subjective appetite and metabolic and endocrine responses. Methods: Using a double blind, randomized cross-over design, 10 healthy lean male subjects will consume a whey protein-polydextrose bar and an iso-energetic control bar as a mid-morning, between-meal snack for 14 consecutive days. The two intervention phases will be separated by a 2-wk washout period. On the first (day 1) and the last day (day 15) of each intervention phase, subjective appetite, voluntary food intake, blood metabolite and endocrine responses to the snacks will be assessed under laboratory conditions. Additionally, participants will be asked to record free-living food intake on days 4, 8 and 12 of the intervention.

Interventions

DIETARY_SUPPLEMENTControl snack

Subjects will consume one snack bar as a between-meal mid-morning snack daily for 15 days.

DIETARY_SUPPLEMENTWhey-protein & polydextrose snack

Subjects will consume one snack bar as a between-meal mid-morning snack daily for 15 days.

Sponsors

Mars, Inc.
CollaboratorINDUSTRY
University of Nottingham
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* BMI 18-25 kg/m2

Exclusion criteria

* Smokers * BMI \<18 \> 25 kg/m2 * Dieting or weight loss * Presence of disease (e.g. diabetes, cardiovascular disease, cancer etc) * Currently regularly taking medications * Restrained eaters (defined as restraint score \>7 on TFEQ)

Design outcomes

Primary

MeasureTime frameDescription
Energy intake at an ad libitum lunchtime test mealDay 1Energy intake at a lunchtime test meal served 90 min following the consumption of the snack bar on day 1.

Secondary

MeasureTime frameDescription
Energy intake at an ad libitum lunchtime test mealDay 15Energy intake at a lunchtime test meal served 90 min following the consumption of the snack bar on day 15.
Subjective appetite responsesDay 1Subjective appetite ratings (hunger, fullness, desire to eat, thirst and nausea) will be recorded when subjects arrive at the laboratory (fasting), prior to the consumption of the snack (-15min), immediately following the consumption of the snack (0 min) and at 30, 60 and 90 min later on day 1.
Remainder of the day energy intakeDay 1Subjects will record all foods and drinks consumed after they leave the laboratory, for the remainder of the day on day 1 in a food diary provided. Total daily energy intake will be calculated from the sum of energy from foods consumed in the laboratory and foods and drinks recorded in the diary.
Free living energy intakeDay 4Subjects will record all foods and drinks consumed on day 4 of the free-living phase of the intervention in a food diary provided.

Other

MeasureTime frameDescription
Metabolic responsesDay 1Blood samples will be collected in response to the snack bars on day 1 and analyzed for glucose, insulin and ffa.
Endocrine responsesDay 1Blood samples will be collected in response to the snack bars on day 1 and analyzed for GLP-1, PYY and ghrelin.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 21, 2026