Acute Diarrhea
Conditions
Keywords
probiotics, diarrhea
Brief summary
* Acute diarrhea continues to be a major cause of childhood morbidity and mortality in developed and developing countries. * Prevention and treatment of dehydration are the mainstays of therapy. Rehydration can be achieved with oral rehydratation solution (ORS). * Even though ORS has reduced the mortality and morbidity very significantly, it has no effect on the duration of diarrhea, stool consistency and frequency and remains underused. * ESPGHAN and ESPID published together an evidence based guideline and stated that in the management of acute gastroenteritis rehydration is the key treatment and that selected probiotics may reduce the duration and intensity of symptoms and can be used as an adjuvant to ORS. * Current evidence also indicates that probiotic effects are strain-specific. Lactobacillus GG and Saccharomyces boulardii are the best studied strains. However, more research is needed to guide the use of particular probiotic regimens and strains and as there is still no evidence of efficacy for many preparations.
Detailed description
Acute diarrhea continues to be a major cause of childhood morbidity and mortality in developed and developing countries. Prevention and treatment of dehydration are the mainstays of therapy. Rehydration can be achieved with oral rehydratation solution (ORS). Even though ORS has reduced the mortality and morbidity very significantly, it has no effect on the duration of diarrhea, stool consistency and frequency and remains underused. ESPGHAN and ESPID published together an evidence based guideline and stated that in the management of acute gastroenteritis rehydration is the key treatment and that selected probiotics may reduce the duration and intensity of symptoms and can be used as an adjuvant to ORS. A recent Cochrane review including 56 trials in children concluded that specific probiotics reduce the duration of diarrhea with about 24 hours and decrease the frequency of defecation on the second day. Current evidence also indicates that probiotic effects are strain-specific. Lactobacillus LGG and Saccharomyces boulardii are the best studied strains. However, more research is needed to guide the use of particular probiotic regimens and strains and as there is still no evidence of efficacy for many preparations. The aim of this study was to evaluate effects of different probiotics on the duration of acute infectious diarrhea.
Interventions
DIETARY_SUPPLEMENTProbiotic
Comparison of probiotics vs. ORS
DIETARY_SUPPLEMENTORS
ORS ad libitum
Sponsors
Eskisehir Osmangazi University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Months to 60 Months
Healthy volunteers
No
Inclusion criteria
* children of both sexes aged between 3 and 60 months, with acute watery diarrhea lasting more than 12 hours but less than 72 hours, requiring hospitalization. Children with clinical signs of mild to moderate dehydration (prolonged capillary refill time, abnormal skin turgor and 3-9% percentage loss of body weight).
Exclusion criteria
* clinical features of hypovolemic shock and/or necessitating admission at the intensive care unit were excluded. Other
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of diarrhea | Day 7 | Duration of diarrhea, since the beginning of the intervention, evaluated with Bristol scoring scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of children with diarrhea at the 3rd day of intervention | Day 3 | Percentage of children with diarrhea at the 3rd day of intervention |
| Duration of hospitalization | Day 5 | Lenght of stay of hoospitalization |
| Safety of probiotics | 5 days of intervention | All clinical conditions (related with probiotics) should be noted. |
Countries
Turkey (Türkiye)
Outcome results
None listed