Sublingual Administration of PPI

Sublingual Administration is More Fast Than Oral or IV Administration in PPI Dosing With Respect to Intragastric pH and Therapeutic Effectiveness: a Prospective, Randomized, Controlled Trial

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01926600

Enrollment

Registered

2013-08-21

Start date

2013-08-31

Completion date

2013-12-31

Last updated

2013-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric or Duodenal Ulcer

Keywords

gastric ulcer, duodenal ulcer, re-bleeding rate, intragastric pH, proton pump inhibitor

Brief summary

Compare 24-hour intragastric pH and therapeutic effectiveness of proton pump inhibitor (PPI) among different administration methods: per oral (PO), intravenous (IV), and sublingual (SL).

Detailed description

Intragastric pH and therapeutic effectiveness of PPI was compared among patients given PPI with different administration methods. 24 hour intragastric pH catheter was inserted in stomach of patients with peptic ulcer an hour prior to PPI administration in order to observe the initial change in pH. Three groups of patients were given PPI through per oral, intravenous, and sublingual administration methods. The hypothesis of this study is that sublingual administration will be faster than oral or IV administration in PPI dosing with respect to intragastric pH change and re-bleeding rate.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients with peptic ulcer disease * Age: 20-75 years old * Patients who submitted informed consent

Exclusion criteria

* Peptic ulcer disease with spurting and oozing * Shock, hypotension, pregnancy * Gastrointestinal malignancy

Design outcomes

Primary

Measure	Time frame
Measure 24-hour intragastric pH	24 hours

Countries

South Korea

Contacts

Primary ContactJin Il Kim, MD

jikim@catholic.ac.kr82-2-3779-1519

Outcome results