Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

Cerebrovascular Autoregulation in Patients With Severe Sepsis and Septic Shock, Influence of Renal Replacement Therapy

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01926301

Acronym

SepsAR2

Enrollment

Registered

2013-08-20

Start date

2013-08-31

Completion date

2020-06-30

Last updated

2020-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock, Severe Sepsis

Keywords

sepsis, cerebrovascular autoregulation, delirium

Brief summary

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation. Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

Interventions

PROCEDUREcontinuous veno-venous hemodialysis

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* severe sepsis or septic shock * adult patients * possibility of transcranial Doppler ultrasound

Exclusion criteria

* traumatic brain injury * known cerebrovascular diseases * Infection of the brain * chronic renal failure * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Cerebrovascular autoregulation	during the first 4 days	Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock

Secondary

Measure	Time frame	Description
Delirium	at day 4	Incidence of Delirium at day 4 after severe sepsis or septic shock

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026