Neonatal Respiratory Distress Syndrome
Conditions
Keywords
Nasal Intermittent Positive-Pressure Ventilation, Nasal Continuous Positive Airway Pressure, twin, respiratory distress syndrome
Brief summary
In the present study, we hypothesized that primary mode nIPPV initiated shortly after birth would decrease the incidence of intubation or death in twin infants when compared to nCPAP.
Detailed description
After inclusion of eligible twins infants,one of the twins was supported by nCPAP and another nIPPV.
Interventions
DEVICEnIPPV
one of the twins was randomly allocated to nIPPV
DEVICEnCPAP
another of the twins was allocated to nCPAP
Sponsors
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Minutes to 6 Hours
Healthy volunteers
No
Inclusion criteria
* Twins * Clinical diagnosis of mild-moderate respiratory distress syndrome * requiring a fraction of inspired oxigen (FiO2 ) \<0.40 to keep oxygen saturation of 90%-95% * a chest X-ray suggestive of early stage hyaline membrane disease, (i.e. mild microgranulia and air bronchogram)
Exclusion criteria
* pneumothorax * pneumomediastinum * surgical diseases * cardiac diseases * intraventricular hemorrage * major congenital defects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of intubation | 48h |
Secondary
| Measure | Time frame |
|---|---|
| incidence of BPD | 1 month |
Other
| Measure | Time frame |
|---|---|
| death | 3 months |
Countries
China
Outcome results
None listed