Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Study of Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01924221

Acronym

RER-CRT

Enrollment

Registered

2013-08-16

Start date

2011-12-31

Completion date

2022-08-01

Last updated

2022-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure, Patients Undergoing CRT-D Device Implantation

Brief summary

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* patients undergoing implantation of a CRT-D

Exclusion criteria

* age \< 18 y * pregnancy or planned pregnancy

Design outcomes

Primary

Measure	Time frame	Description
correlation between electrical and mechanical remodeling	6 months after CRT implantation	correlation between electrical and mechanical measures of dyssynchrony

Countries

United States

Outcome results