Post Operative Sore Throat
Conditions
Keywords
Magnesium, Post operative sore throat, Prone position, Tracheal intubation
Brief summary
The purpose of this study is to compare the effect of magnesium sulfate and dexamethasone on postoperative sore throat after spinal surgery in prone position with tracheal intubation.
Interventions
DRUGMagnesium Sulfate
Magnesium sulfate 30 mg kg-1 was infused in 100mL normal saline for 10 minutes immediately before anesthesia induction. After tracheal intubation, normal saline 1.6mL ( equivalent volume as Dexamethasone 8mg) was injected, and magnesium sulfate was continuously infused at the rate of 10 mg Kg-1 h-1 until the end of surgery. (at the time of skin closure)
DRUGdexamethasone
Normal saline 100mL was infused for 10 minutes immediately before anesthesia induction. After tracheal intubation, dexamethasone 8mg was injected, and normal saline was continuously infused at the rate of 10 mg Kg-1 h-1 until the end of surgery. (at the time of skin closure)
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II patients aged between 20 and 65 year undergoing 1 or 2 level posterior spinal fusion in prone position with tracheal intubation
Exclusion criteria
* preexisting hoarseness or sore throat, upper respiratory tract infection * steroid therapy or immunocompromised patients * chronic treatment with calcium channel blocker or magnesium * allergy to magnesium sulphate * Cormack-Lehane grade 3,4 or patients who are expected to difficult intubation * fail to tracheal intubation at first trial * reduced kidney function * Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The effect of magnesium sulfate on postoperative sore throat after spinal surgery in prone position with tracheal intubation | Change of post operative sore throat level from 1 to 48 hours after surgery | Incidence of post operative sore throat Severity of post operative sore throat (10 cm-visual analogue scale ) Incidence of post operative hoarseness Severity of post operative hoarseness ( four-graded scale, 0= no hoarseness, 1= mild hoarseness, 2= severe hoarseness, 3= aphonia) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The effect of dexamethasone on postoperative sore throat after spinal surgery in prone position with tracheal intubation | Change of post operative sore throat level from 1 to 48 hours after surgery | Incidence of post operative sore throat Severity of post operative sore throat (10 cm-visual analogue scale ) Incidence of post operative hoarseness Severity of post operative hoarseness ( four-graded scale, 0= no hoarseness, 1= mild hoarseness, 2= severe hoarseness, 3= aphonia) |
Countries
South Korea
Outcome results
None listed