Allergy
Conditions
Brief summary
The respiratory epithelium plays a leading role in the development of allergic respiratory disease with barrier function alteration, its repair mechanisms, of anti-viral fight and the ability to induce by itself Th2 responses. The majority of allergic asthmatic patients have reached concomitant ENT: the concept of "one airway, one disease." Access to this material of epithelial study in the different phenotypes of the disease appears to be crucial. Nasal and bronchial epithelial tissues reveal essential differences in particular related to their environment (remodeling less intense and a lower sensitivity to the virus in the nose), but they nevertheless share many common cellular characteristics.
Interventions
PROCEDUREbronchofiberscopy
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* age ≥ 18 years and \<30 years * isolated allergic rhinitis according to clinical criteria ARIA * absence of asthma whose diagnosis is made based on clinical criteria or mild to moderate persistent asthma controlled with a diagnosis is made based on clinical criteria
Exclusion criteria
* recent rhino-bronchial infection (\<6 weeks) * asthma exacerbation in the previous 6 weeks * Chronic disease may in the opinion of the investigators interfere with the results of the study or expose them to additional risk. * Treatment with nasal corticosteroids, inhaled or systemic in the past 6 weeks * Current smoking no history of smoking or not smoking for at least 12 months and weaned smoking history \<5 pack-years) * Special Needs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genic expression profile of the epithelium | 3 months after inclusion |
Countries
France
Outcome results
None listed