Parenteral Nutrition (No Primary Condition Studied)
Conditions
Brief summary
The purpose of this study is to determine the best rate of infusion of amino acids (15% CLINISOL - sulfite-free (Amino Acid) Injection) for nutrition in subjects with with stages II to IVB head and neck cancer.
Interventions
DRUG15% CLINISOL - Sulfite-free (Amino Acid) Injection
Sponsors
Baxter Healthcare Corporation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Have Stages II to IVB head and neck cancer receiving radiation and may also be receiving chemotherapy. \* Subjects are eligible for inclusion in the study regardless of primary Stages II to IVB head and neck cancer treatment modality (eg, surgery, chemotherapy). * Have voluntarily signed and dated a written informed consent form (ICF) after the nature of the study was explained to them. * Female subjects must be of non childbearing potential (defined as postmenopausal for at least 1 year or surgically sterile \[bilateral tubal ligation, bilateral oophorectomy or hysterectomy\]) or; * Female subjects of childbearing potential must be using adequate contraception (practicing 1 of the following methods of birth control): * total abstinence from sexual intercourse (minimum of 1 complete menstrual cycle before study entry), * a vasectomized partner, * contraceptives (oral, parenteral, or transdermal) for 3 consecutive months prior to study drug administration, * intrauterine device (IUD), or * double barrier method (condoms, sponge, diaphragm, or vaginal ring with spermicidal jellies or cream). * Female subjects must have a negative serum or urinary pregnancy test result at screening (serum specimen must be obtained within 14 days prior to baseline).
Exclusion criteria
* Had a loss of \> 10% of body weight within the 3 month period prior to the study as noted in the subjects medical history chart. * Have renal disease as determined by an estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m2. * Have a hemoglobin level of \< 9 g/dl. * Have Stage 0, I, or IVC metastatic cancer. * Have diabetes. * Have any reason which, in the opinion of the Investigator, would prevent the subject from safely participating in the study. * Have, in the opinion of the Investigator, a dependence on alcohol. * Have, in the opinion of the Investigator, a dependence on illicit drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Net Protein Synthesis | One time at pre-clinisol infusion and one time at post-clinisol infusion |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Concentration of Glucose | Nine times during each 7 hour visit |
| Serum Concentration of Insulin | Five times during each 7 hour visit |
| Plasma Stable Isotope Enrichment of Phenylalanine | Twelve times during each 7 hour visit |
| Plasma Stable Isotope Enrichment of Tyrosine | Twelve times during each 7 hour visit |
| Plasma Concentration of Alanine | Three times during each 7 hour visit |
| Plasma Concentration of Arginine | Three times during each 7 hour visit |
| Plasma Concentration of Aspartic Acid | Three times during each 7 hour visit |
| Plasma Concentration of Glutamic Acid | Three times during each 7 hour visit |
| Plasma Concentration of Glutamine | Three times during each 7 hour visit |
| Plasma Concentration of Glycine | Three times during each 7 hour visit |
| Plasma Concentration of Histidine | Three times during each 7 hour visit |
| Insulin Sensitivity | Five times during each 7 hour visit |
| Plasma Concentration of Leucine | Three times during each 7 hour visit |
| Plasma Concentration of Lysine | Three times during each 7 hour visit |
| Plasma Concentration of Methionine | Three times during each 7 hour visit |
| Plasma Concentration of Ornithine | Three times during each 7 hour visit |
| Plasma Concentration of Phenylalanine | Three times during each 7 hour visit |
| Plasma Concentration of Proline | Three times during each 7 hour visit |
| Plasma Concentration of Serine | Three times during each 7 hour visit |
| Plasma Concentration of Taurine | Three times during each 7 hour visit |
| Plasma Concentration of Threonine | Three times during each 7 hour visit |
| Plasma Concentration of Tyrosine | Three times during each 7 hour visit |
| Plasma Concentration of Valine | Three times during each 7 hour visit |
| Plasma Concentration of Isoleucine | Three times during each 7 hour visit |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| 15% CLINISOL 0.04 g/kg/hr 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.04 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection.
15% CLINISOL - Sulfite-free (Amino Acid) Injection | 3 |
| 15% CLINISOL 0.08 g/kg/hr 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.08 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection.
15% CLINISOL - Sulfite-free (Amino Acid) Injection | 4 |
| 15% CLINISOL 0.13 g/kg/hr 15% CLINISOL- Sulfite-Free (Amino Acid)Injection 0.13 g/kg/hr to be administered. Each treatment session is expected to last 7 hours with the first 3 hours of basal infusion followed by 4 hours of 15% CLINISOL - Sulfite-Free (Amino Acid) Injection.
15% CLINISOL - Sulfite-free (Amino Acid) Injection | 4 |
| Total | 11 |
Baseline characteristics
| Characteristic | 15% CLINISOL 0.04 g/kg/hr | 15% CLINISOL 0.08 g/kg/hr | 15% CLINISOL 0.13 g/kg/hr | Total |
|---|---|---|---|---|
| Age, Continuous | 60.33 Years STANDARD_DEVIATION 10.5 | 69.25 Years STANDARD_DEVIATION 14.93 | 60.50 Years STANDARD_DEVIATION 6.4 | 63.64 Years STANDARD_DEVIATION 11 |
| Sex: Female, Male Female | 2 Participants | 2 Participants | 3 Participants | 7 Participants |
| Sex: Female, Male Male | 1 Participants | 2 Participants | 1 Participants | 4 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk |
|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — |
| other Total, other adverse events | 2 / 3 | 0 / 4 | 0 / 4 |
| serious Total, serious adverse events | 0 / 3 | 0 / 4 | 0 / 4 |
Outcome results
Primary
Change in Net Protein Synthesis
Time frame: One time at pre-clinisol infusion and one time at post-clinisol infusion
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 1 | 2.82 g protein/d/kg ffm | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 2 | 2.6 g protein/d/kg ffm | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 1 | 3.15 g protein/d/kg ffm | Standard Deviation 0.38 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 2 | 2.83 g protein/d/kg ffm | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 1 | 4.92 g protein/d/kg ffm | Standard Deviation 0.45 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 2 | 6.13 g protein/d/kg ffm | Standard Deviation 0.62 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 1 | 11.62 g protein/d/kg ffm | Standard Deviation 6.67 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 2 | 4.89 g protein/d/kg ffm | Standard Deviation 0.81 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 1 | 6.11 g protein/d/kg ffm | Standard Deviation 2.46 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Change in Net Protein Synthesis | Period 2 | 9.10 g protein/d/kg ffm | Standard Deviation 2.52 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 1 | 9.15 g protein/d/kg ffm | Standard Deviation 2.64 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Change in Net Protein Synthesis | Period 2 | 8.29 g protein/d/kg ffm | Standard Deviation 0.88 |
Secondary
Insulin Sensitivity
Time frame: Five times during each 7 hour visit
Population: No data available as no data for this outcome measure were collected during the study.
Secondary
Plasma Concentration of Alanine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 364.9 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 499.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 440.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 340.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 438.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 452.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 292.9 micromol/L | Standard Deviation 36.73 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 425.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 463.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 239.6 micromol/L | Standard Deviation 2.09 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 359.6 micromol/L | Standard Deviation 46.67 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 407.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 425.8 micromol/L | Standard Deviation 11.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 414.4 micromol/L | Standard Deviation 86.71 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 240.5 micromol/L | Standard Deviation 8.59 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 388.9 micromol/L | Standard Deviation 10.32 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 212.4 micromol/L | Standard Deviation 7.83 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 347.5 micromol/L | Standard Deviation 3.14 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 449.5 micromol/L | Standard Deviation 221.3 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 648.9 micromol/L | Standard Deviation 73.64 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 645.1 micromol/L | Standard Deviation 126.4 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 770.3 micromol/L | Standard Deviation 254.9 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 813.7 micromol/L | Standard Deviation 269.6 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 321.5 micromol/L | Standard Deviation 3.85 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 284.8 micromol/L | Standard Deviation 199.2 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 631.5 micromol/L | Standard Deviation 292.7 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 468.1 micromol/L | Standard Deviation 195.4 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 414.4 micromol/L | Standard Deviation 101.8 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 346.1 micromol/L | Standard Deviation 266.3 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 573.0 micromol/L | Standard Deviation 209 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 3hrs | 522.7 micromol/L | Standard Deviation 258.7 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 7hrs | 959.3 micromol/L | Standard Deviation 481.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 4.5hrs | 938.9 micromol/L | Standard Deviation 436 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 2 @ 7hrs | 976.6 micromol/L | Standard Deviation 483.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 4.5hrs | 840.3 micromol/L | Standard Deviation 304.2 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Alanine | Period 1 @ 3hrs | 428.2 micromol/L | Standard Deviation 63 |
Secondary
Plasma Concentration of Arginine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 98.48 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 153.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 160.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 84.17 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 120.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 130.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 88.42 micromol/L | Standard Deviation 22.85 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 81.10 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 139.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 69.25 micromol/L | Standard Deviation 11.33 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 94.35 micromol/L | Standard Deviation 3.58 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 115.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 152.7 micromol/L | Standard Deviation 9.45 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 151.6 micromol/L | Standard Deviation 34.59 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 85.71 micromol/L | Standard Deviation 30.99 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 159.7 micromol/L | Standard Deviation 27.81 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 71.35 micromol/L | Standard Deviation 17.4 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 145.8 micromol/L | Standard Deviation 28.74 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 72.54 micromol/L | Standard Deviation 7.09 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 160.1 micromol/L | Standard Deviation 13.87 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 173.2 micromol/L | Standard Deviation 2.28 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 221.9 micromol/L | Standard Deviation 36.78 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 195.6 micromol/L | Standard Deviation 9.68 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 61.34 micromol/L | Standard Deviation 2.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 82.74 micromol/L | Standard Deviation 39.22 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 204.1 micromol/L | Standard Deviation 99.12 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 171.9 micromol/L | Standard Deviation 16.72 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 167.8 micromol/L | Standard Deviation 6.87 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 79.34 micromol/L | Standard Deviation 29.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 200.9 micromol/L | Standard Deviation 102.1 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 3hrs | 100.7 micromol/L | Standard Deviation 22.21 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 7hrs | 307.9 micromol/L | Standard Deviation 108.7 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 4.5hrs | 284.2 micromol/L | Standard Deviation 86.42 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 2 @ 7hrs | 294.3 micromol/L | Standard Deviation 86.06 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 4.5hrs | 276.6 micromol/L | Standard Deviation 75.96 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Arginine | Period 1 @ 3hrs | 88.24 micromol/L | Standard Deviation 5.66 |
Secondary
Plasma Concentration of Aspartic Acid
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 3.98 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 10.47 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 10.95 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 2.87 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 7.57 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 7.99 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 4.13 micromol/L | Standard Deviation 2.79 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 2.52 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 4.07 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 1.95 micromol/L | Standard Deviation 0.39 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 2.43 micromol/L | Standard Deviation 0.59 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 4.21 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 8.98 micromol/L | Standard Deviation 8.13 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 6.55 micromol/L | Standard Deviation 1.89 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 2.40 micromol/L | Standard Deviation 1.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 9.24 micromol/L | Standard Deviation 0.57 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 2.18 micromol/L | Standard Deviation 0.61 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 9.52 micromol/L | Standard Deviation 2.68 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 2.92 micromol/L | Standard Deviation 0.55 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 9.60 micromol/L | Standard Deviation 0.67 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 9.04 micromol/L | Standard Deviation 3.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 11.11 micromol/L | Standard Deviation 1.2 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 11.67 micromol/L | Standard Deviation 0.36 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 2.53 micromol/L | Standard Deviation 0.12 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 2.88 micromol/L | Standard Deviation 0.17 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 15.38 micromol/L | Standard Deviation 4.19 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 12.56 micromol/L | Standard Deviation 1.12 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 9.73 micromol/L | Standard Deviation 0.98 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 3.71 micromol/L | Standard Deviation 1.35 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 15.43 micromol/L | Standard Deviation 2.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 3hrs | 3.76 micromol/L | Standard Deviation 1.28 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 7hrs | 31.28 micromol/L | Standard Deviation 11.53 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 4.5hrs | 22.67 micromol/L | Standard Deviation 0.95 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 2 @ 7hrs | 21.79 micromol/L | Standard Deviation 0.23 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 4.5hrs | 23.45 micromol/L | Standard Deviation 1.58 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Aspartic Acid | Period 1 @ 3hrs | 3.27 micromol/L | Standard Deviation 0.66 |
Secondary
Plasma Concentration of Glucose
Time frame: Nine times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2. One subject in grp 0.04 g/kg/hr, seq BA, plasma concentration of glucose was not collected at any time point during Period 1.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 93.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 86.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 93.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 95.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 97.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 103.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 101.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 86.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 110.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 108.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 103.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 103.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 100.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 101.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 95.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 97.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 99.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 97.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 91.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 92.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 81.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 102.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 111.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 89.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 75.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 69.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 99.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 102.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 97.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 104.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 103.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 103.00 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 104.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 106.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 102.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 105.0 mg/dL | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 94.00 mg/dL | Standard Deviation 5.66 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 96.50 mg/dL | Standard Deviation 3.54 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 88.00 mg/dL | Standard Deviation 2.83 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 94.50 mg/dL | Standard Deviation 3.54 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 90.00 mg/dL | Standard Deviation 4.24 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 90.50 mg/dL | Standard Deviation 28.99 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 88.00 mg/dL | Standard Deviation 32.53 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 93.00 mg/dL | Standard Deviation 9.9 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 93.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 90.50 mg/dL | Standard Deviation 6.36 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 75.00 mg/dL | Standard Deviation 2.83 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 95.00 mg/dL | Standard Deviation 8.49 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 93.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 84.50 mg/dL | Standard Deviation 4.95 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 91.50 mg/dL | Standard Deviation 2.12 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 95.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 93.00 mg/dL | Standard Deviation 5.66 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 92.00 mg/dL | Standard Deviation 9.9 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 92.50 mg/dL | Standard Deviation 3.54 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 93.50 mg/dL | Standard Deviation 2.12 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 98.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 97.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 86.50 mg/dL | Standard Deviation 0.71 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 103.5 mg/dL | Standard Deviation 6.36 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 96.00 mg/dL | Standard Deviation 4.24 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 101.0 mg/dL | Standard Deviation 5.66 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 99.50 mg/dL | Standard Deviation 4.95 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 94.00 mg/dL | Standard Deviation 8.49 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 98.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 99.00 mg/dL | Standard Deviation 4.24 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 98.00 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 100.5 mg/dL | Standard Deviation 0.71 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 105.0 mg/dL | Standard Deviation 7.07 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 90.00 mg/dL | Standard Deviation 12.73 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 92.50 mg/dL | Standard Deviation 7.78 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 97.00 mg/dL | Standard Deviation 11.31 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 101.0 mg/dL | Standard Deviation 15.56 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 102.5 mg/dL | Standard Deviation 20.51 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 104.5 mg/dL | Standard Deviation 13.44 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 103.0 mg/dL | Standard Deviation 26.87 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 101.5 mg/dL | Standard Deviation 14.85 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 104.5 mg/dL | Standard Deviation 19.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 100.0 mg/dL | Standard Deviation 11.31 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 112.5 mg/dL | Standard Deviation 7.78 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 102.0 mg/dL | Standard Deviation 21.21 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 107.0 mg/dL | Standard Deviation 1.41 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 105.5 mg/dL | Standard Deviation 14.85 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 107.50 mg/dL | Standard Deviation 14.85 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 101.5 mg/dL | Standard Deviation 9.19 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 105.0 mg/dL | Standard Deviation 4.24 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 99.00 mg/dL | Standard Deviation 45.25 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 104.0 mg/dL | Standard Deviation 19.8 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 103.5 mg/dL | Standard Deviation 13.44 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 100.5 mg/dL | Standard Deviation 37.48 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3.5hrs | 111.5 mg/dL | Standard Deviation 7.78 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6hrs | 100.0 mg/dL | Standard Deviation 8.49 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 7hrs | 93.50 mg/dL | Standard Deviation 2.12 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 6.5hrs | 98.00 mg/dL | Standard Deviation 8.49 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3hrs | 94.50 mg/dL | Standard Deviation 9.19 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4.5hrs | 100.0 mg/dL | Standard Deviation 7.07 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 3.5hrs | 100.0 mg/dL | Standard Deviation 8.49 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 7hrs | 98.50 mg/dL | Standard Deviation 10.61 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6.5hrs | 95.00 mg/dL | Standard Deviation 7.78 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5hrs | 95.50 mg/dL | Standard Deviation 9.19 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4.5hrs | 105.5 mg/dL | Standard Deviation 7.78 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5hrs | 100.0 mg/dL | Standard Deviation 9.9 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 3hrs | 95.00 mg/dL | Standard Deviation 7.07 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 5.5hrs | 96.50 mg/dL | Standard Deviation 9.19 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 4hrs | 110.0 mg/dL | Standard Deviation 15.56 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 1 @ 6hrs | 93.50 mg/dL | Standard Deviation 9.19 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 4hrs | 103.5 mg/dL | Standard Deviation 6.36 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glucose | Period 2 @ 5.5hrs | 101.5 mg/dL | Standard Deviation 10.61 |
Secondary
Plasma Concentration of Glutamic Acid
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 586.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 634.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 647.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 587.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 510.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 489.2 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 599.5 micromol/L | Standard Deviation 167.4 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 884.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 854.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 659.1 micromol/L | Standard Deviation 120.1 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 661.2 micromol/L | Standard Deviation 93.35 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 926.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 510.0 micromol/L | Standard Deviation 123.1 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 563.5 micromol/L | Standard Deviation 150.4 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 588.9 micromol/L | Standard Deviation 138.8 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 573.7 micromol/L | Standard Deviation 131 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 561.1 micromol/L | Standard Deviation 108.5 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 561.9 micromol/L | Standard Deviation 179 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 722.5 micromol/L | Standard Deviation 125.8 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 647.9 micromol/L | Standard Deviation 48.97 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 560.1 micromol/L | Standard Deviation 99.21 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 735.0 micromol/L | Standard Deviation 215.9 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 811.7 micromol/L | Standard Deviation 159.9 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 678.3 micromol/L | Standard Deviation 28.45 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 588.4 micromol/L | Standard Deviation 172.6 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 606.9 micromol/L | Standard Deviation 111.6 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 646.6 micromol/L | Standard Deviation 158.3 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 576.0 micromol/L | Standard Deviation 98.2 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 607.5 micromol/L | Standard Deviation 119.3 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 531.4 micromol/L | Standard Deviation 72.39 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 3hrs | 727.1 micromol/L | Standard Deviation 153.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 7hrs | 710.8 micromol/L | Standard Deviation 211.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 4.5hrs | 809.3 micromol/L | Standard Deviation 180.6 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 2 @ 7hrs | 808.6 micromol/L | Standard Deviation 237.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 4.5hrs | 690.9 micromol/L | Standard Deviation 100.7 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamic Acid | Period 1 @ 3hrs | 644.8 micromol/L | Standard Deviation 27.42 |
Secondary
Plasma Concentration of Glutamine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 75.20 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 99.73 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 100.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 71.27 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 72.71 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 71.57 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 25.08 micromol/L | Standard Deviation 1.92 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 17.48 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 24.35 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 25.55 micromol/L | Standard Deviation 11.72 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 18.58 micromol/L | Standard Deviation 5.77 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 20.70 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 54.79 micromol/L | Standard Deviation 49.63 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 51.03 micromol/L | Standard Deviation 22.43 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 40.23 micromol/L | Standard Deviation 14.76 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 68.48 micromol/L | Standard Deviation 14.21 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 43.94 micromol/L | Standard Deviation 15.4 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 70.98 micromol/L | Standard Deviation 27.55 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 57.03 micromol/L | Standard Deviation 18.79 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 65.68 micromol/L | Standard Deviation 2.2 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 60.20 micromol/L | Standard Deviation 17.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 85.71 micromol/L | Standard Deviation 16.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 84.88 micromol/L | Standard Deviation 7.67 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 46.75 micromol/L | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 60.22 micromol/L | Standard Deviation 29.73 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 106.0 micromol/L | Standard Deviation 44.36 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 105.1 micromol/L | Standard Deviation 38.45 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 92.00 micromol/L | Standard Deviation 25.1 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 67.96 micromol/L | Standard Deviation 21.47 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 103.5 micromol/L | Standard Deviation 35.21 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 3hrs | 68.15 micromol/L | Standard Deviation 19.74 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 7hrs | 175.10 micromol/L | Standard Deviation 30.72 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 4.5hrs | 137.0 micromol/L | Standard Deviation 15.99 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 2 @ 7hrs | 131.1 micromol/L | Standard Deviation 13.87 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 4.5hrs | 142.3 micromol/L | Standard Deviation 18.79 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glutamine | Period 1 @ 3hrs | 69.89 micromol/L | Standard Deviation 18.67 |
Secondary
Plasma Concentration of Glycine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 217.2 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 304.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 307.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 215.9 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 252.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 278.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 316.8 micromol/L | Standard Deviation 113.2 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 316.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 409.9 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 282.2 micromol/L | Standard Deviation 68.99 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 388.4 micromol/L | Standard Deviation 63.14 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 372.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 272.9 micromol/L | Standard Deviation 21.39 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 272.2 micromol/L | Standard Deviation 50.56 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 196.7 micromol/L | Standard Deviation 33.5 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 248.7 micromol/L | Standard Deviation 8.33 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 164.4 micromol/L | Standard Deviation 0.97 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 243.6 micromol/L | Standard Deviation 9.33 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 210.1 micromol/L | Standard Deviation 45.73 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 332.3 micromol/L | Standard Deviation 37.75 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 331.70 micromol/L | Standard Deviation 32.97 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 383.2 micromol/L | Standard Deviation 77.85 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 394.9 micromol/L | Standard Deviation 73.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 188.9 micromol/L | Standard Deviation 20.63 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 153.2 micromol/L | Standard Deviation 23.8 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 318.1 micromol/L | Standard Deviation 94.07 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 254.0 micromol/L | Standard Deviation 8.27 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 234.5 micromol/L | Standard Deviation 13.48 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 162.3 micromol/L | Standard Deviation 17.64 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 315.0 micromol/L | Standard Deviation 48.7 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 3hrs | 223.8 micromol/L | Standard Deviation 73.09 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 7hrs | 477.0 micromol/L | Standard Deviation 214.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 4.5hrs | 473.2 micromol/L | Standard Deviation 194.6 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 2 @ 7hrs | 481.5 micromol/L | Standard Deviation 207 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 4.5hrs | 417.6 micromol/L | Standard Deviation 142.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Glycine | Period 1 @ 3hrs | 183.2 micromol/L | Standard Deviation 16.61 |
Secondary
Plasma Concentration of Histidine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 59.79 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 102.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 105.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 57.64 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 78.64 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 92.85 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 85.49 micromol/L | Standard Deviation 35.85 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 82.09 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 122.2 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 68.48 micromol/L | Standard Deviation 23.33 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 101.5 micromol/L | Standard Deviation 27.27 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 107.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 96.02 micromol/L | Standard Deviation 6.94 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 88.02 micromol/L | Standard Deviation 1.17 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 49.86 micromol/L | Standard Deviation 8.74 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 102.0 micromol/L | Standard Deviation 5.5 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 53.21 micromol/L | Standard Deviation 3.43 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 92.18 micromol/L | Standard Deviation 6.92 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 68.17 micromol/L | Standard Deviation 14.31 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 127.80 micromol/L | Standard Deviation 0.95 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 134.2 micromol/L | Standard Deviation 5.65 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 166.2 micromol/L | Standard Deviation 6.55 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 147.5 micromol/L | Standard Deviation 12.87 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 64.81 micromol/L | Standard Deviation 11.94 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 60.28 micromol/L | Standard Deviation 17.9 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 131.1 micromol/L | Standard Deviation 30.02 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 110.7 micromol/L | Standard Deviation 11.7 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 109.5 micromol/L | Standard Deviation 0.79 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 64.02 micromol/L | Standard Deviation 3.67 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 130.3 micromol/L | Standard Deviation 15.85 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 3hrs | 73.54 micromol/L | Standard Deviation 3.86 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 7hrs | 257.0 micromol/L | Standard Deviation 157.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 4.5hrs | 186.4 micromol/L | Standard Deviation 57.07 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 2 @ 7hrs | 217.7 micromol/L | Standard Deviation 99.88 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 4.5hrs | 189.8 micromol/L | Standard Deviation 65.2 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Histidine | Period 1 @ 3hrs | 67.55 micromol/L | Standard Deviation 6.56 |
Secondary
Plasma Concentration of Isoleucine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 78.62 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 113.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 122.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 61.12 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 76.59 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 77.31 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 46.11 micromol/L | Standard Deviation 2.99 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 44.49 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 89.49 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 44.71 micromol/L | Standard Deviation 1.33 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 47.07 micromol/L | Standard Deviation 0.78 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 69.09 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 108.9 micromol/L | Standard Deviation 72.63 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 105.8 micromol/L | Standard Deviation 47.35 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 77.59 micromol/L | Standard Deviation 36.35 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 141.5 micromol/L | Standard Deviation 25.44 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 51.67 micromol/L | Standard Deviation 9.86 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 106.6 micromol/L | Standard Deviation 12.32 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 64.74 micromol/L | Standard Deviation 15.58 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 111.2 micromol/L | Standard Deviation 2.28 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 116.3 micromol/L | Standard Deviation 4.68 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 181.3 micromol/L | Standard Deviation 12.57 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 142.9 micromol/L | Standard Deviation 17.86 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 62.79 micromol/L | Standard Deviation 4.14 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 58.87 micromol/L | Standard Deviation 22.53 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 127.7 micromol/L | Standard Deviation 77.87 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 112.1 micromol/L | Standard Deviation 8.92 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 138.3 micromol/L | Standard Deviation 8.17 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 53.35 micromol/L | Standard Deviation 30 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 137.3 micromol/L | Standard Deviation 99.68 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 3hrs | 76.08 micromol/L | Standard Deviation 8.34 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 7hrs | 247.5 micromol/L | Standard Deviation 122 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 4.5hrs | 193.5 micromol/L | Standard Deviation 38.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 2 @ 7hrs | 228.1 micromol/L | Standard Deviation 64.48 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 4.5hrs | 192.9 micromol/L | Standard Deviation 68.37 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Isoleucine | Period 1 @ 3hrs | 73.22 micromol/L | Standard Deviation 0.92 |
Secondary
Plasma Concentration of Leucine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 105.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 144.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 150.00 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 85.48 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 98.69 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 94.28 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 76.54 micromol/L | Standard Deviation 0.83 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 77.60 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 135.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 88.40 micromol/L | Standard Deviation 1.63 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 71.11 micromol/L | Standard Deviation 5.83 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 112.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 124.4 micromol/L | Standard Deviation 93.67 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 130.9 micromol/L | Standard Deviation 74.81 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 105.3 micromol/L | Standard Deviation 64.54 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 199.3 micromol/L | Standard Deviation 42.32 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 88.55 micromol/L | Standard Deviation 20.92 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 156.9 micromol/L | Standard Deviation 27.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 84.90 micromol/L | Standard Deviation 22.05 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 137.8 micromol/L | Standard Deviation 0.51 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 134.0 micromol/L | Standard Deviation 18.3 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 218.6 micromol/L | Standard Deviation 9.36 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 179.5 micromol/L | Standard Deviation 30.22 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 83.72 micromol/L | Standard Deviation 8.61 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 90.14 micromol/L | Standard Deviation 30.71 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 173.9 micromol/L | Standard Deviation 83.38 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 157.2 micromol/L | Standard Deviation 16.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 180.0 micromol/L | Standard Deviation 10.33 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 92.46 micromol/L | Standard Deviation 12.77 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 186.9 micromol/L | Standard Deviation 114.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 3hrs | 131.0 micromol/L | Standard Deviation 8.08 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 7hrs | 344.6 micromol/L | Standard Deviation 173.9 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 4.5hrs | 277.6 micromol/L | Standard Deviation 71.59 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 2 @ 7hrs | 326.3 micromol/L | Standard Deviation 101.7 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 4.5hrs | 270.9 micromol/L | Standard Deviation 88.68 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Leucine | Period 1 @ 3hrs | 124.3 micromol/L | Standard Deviation 1.61 |
Secondary
Plasma Concentration of Lysine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 169.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 213.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 212.2 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 160.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 189.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 205.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 167.4 micromol/L | Standard Deviation 6.38 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 132.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 206.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 153.5 micromol/L | Standard Deviation 23.62 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 183.2 micromol/L | Standard Deviation 41.15 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 172.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 209.7 micromol/L | Standard Deviation 45.73 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 203.2 micromol/L | Standard Deviation 15.35 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 140.6 micromol/L | Standard Deviation 17.39 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 224.0 micromol/L | Standard Deviation 11.58 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 137.8 micromol/L | Standard Deviation 9.5 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 208.7 micromol/L | Standard Deviation 11.18 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 154.6 micromol/L | Standard Deviation 9.27 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 254.1 micromol/L | Standard Deviation 18.31 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 252.1 micromol/L | Standard Deviation 25.75 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 303.8 micromol/L | Standard Deviation 49.51 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 289.3 micromol/L | Standard Deviation 15.13 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 152.2 micromol/L | Standard Deviation 1.9 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 150.8 micromol/L | Standard Deviation 49.38 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 279.6 micromol/L | Standard Deviation 95.81 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 246.0 micromol/L | Standard Deviation 25.41 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 235.10 micromol/L | Standard Deviation 16.79 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 157.6 micromol/L | Standard Deviation 29.6 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 278.3 micromol/L | Standard Deviation 105 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 3hrs | 234.4 micromol/L | Standard Deviation 3.42 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 7hrs | 461.7 micromol/L | Standard Deviation 109.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 4.5hrs | 429.3 micromol/L | Standard Deviation 69.88 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 2 @ 7hrs | 437.7 micromol/L | Standard Deviation 56.65 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 4.5hrs | 396.5 micromol/L | Standard Deviation 50.69 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Lysine | Period 1 @ 3hrs | 205.8 micromol/L | Standard Deviation 37.52 |
Secondary
Plasma Concentration of Methionine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 22.79 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 53.19 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 61.44 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 19.18 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 43.63 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 53.57 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 35.06 micromol/L | Standard Deviation 3.34 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 28.76 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 62.97 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 20.33 micromol/L | Standard Deviation 2.29 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 48.44 micromol/L | Standard Deviation 3.8 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 47.99 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 69.01 micromol/L | Standard Deviation 9.43 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 54.89 micromol/L | Standard Deviation 1.38 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 18.35 micromol/L | Standard Deviation 1.83 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 69.93 micromol/L | Standard Deviation 1 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 17.88 micromol/L | Standard Deviation 1.83 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 56.60 micromol/L | Standard Deviation 2.19 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 20.07 micromol/L | Standard Deviation 0.15 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 77.47 micromol/L | Standard Deviation 9.77 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 99.33 micromol/L | Standard Deviation 7.3 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 177.2 micromol/L | Standard Deviation 18.41 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 86.24 micromol/L | Standard Deviation 3.05 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 21.20 micromol/L | Standard Deviation 0.23 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 15.96 micromol/L | Standard Deviation 4.54 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 82.96 micromol/L | Standard Deviation 31.71 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 58.39 micromol/L | Standard Deviation 5.08 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 64.98 micromol/L | Standard Deviation 12.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 15.98 micromol/L | Standard Deviation 4.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 103.8 micromol/L | Standard Deviation 45.25 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 3hrs | 26.73 micromol/L | Standard Deviation 6.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 7hrs | 218.50 micromol/L | Standard Deviation 140.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 4.5hrs | 127.9 micromol/L | Standard Deviation 52.59 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 2 @ 7hrs | 186.6 micromol/L | Standard Deviation 100.9 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 4.5hrs | 132.5 micromol/L | Standard Deviation 57.06 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Methionine | Period 1 @ 3hrs | 23.39 micromol/L | Standard Deviation 0.55 |
Secondary
Plasma Concentration of Ornithine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 65.99 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 76.46 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 73.94 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 44.10 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 47.40 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 53.58 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 53.26 micromol/L | Standard Deviation 6.92 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 53.40 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 80.14 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 56.25 micromol/L | Standard Deviation 6.89 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 60.75 micromol/L | Standard Deviation 10.88 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 63.29 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 81.59 micromol/L | Standard Deviation 36.61 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 68.22 micromol/L | Standard Deviation 13.24 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 55.20 micromol/L | Standard Deviation 0.77 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 111.3 micromol/L | Standard Deviation 7.29 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 48.50 micromol/L | Standard Deviation 6.93 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 74.83 micromol/L | Standard Deviation 6.75 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 45.40 micromol/L | Standard Deviation 2.81 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 52.15 micromol/L | Standard Deviation 2.32 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 70.69 micromol/L | Standard Deviation 2.96 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 97.83 micromol/L | Standard Deviation 16.31 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 69.56 micromol/L | Standard Deviation 5.56 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 36.15 micromol/L | Standard Deviation 2.64 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 62.47 micromol/L | Standard Deviation 1.51 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 91.27 micromol/L | Standard Deviation 0.83 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 94.60 micromol/L | Standard Deviation 18.24 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 111.1 micromol/L | Standard Deviation 22.55 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 66.82 micromol/L | Standard Deviation 11 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 113.3 micromol/L | Standard Deviation 29.62 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 3hrs | 71.57 micromol/L | Standard Deviation 14.1 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 7hrs | 183.1 micromol/L | Standard Deviation 70.92 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 4.5hrs | 104.6 micromol/L | Standard Deviation 15.46 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 2 @ 7hrs | 145.1 micromol/L | Standard Deviation 8.72 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 4.5hrs | 117.0 micromol/L | Standard Deviation 22.25 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Ornithine | Period 1 @ 3hrs | 72.31 micromol/L | Standard Deviation 0.38 |
Secondary
Plasma Concentration of Phenylalanine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 64.83 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 105.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 119.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 59.96 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 91.84 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 107.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 79.75 micromol/L | Standard Deviation 0.39 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 65.00 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 99.77 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 62.14 micromol/L | Standard Deviation 9.96 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 106.2 micromol/L | Standard Deviation 22.37 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 86.46 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 128.3 micromol/L | Standard Deviation 18.08 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 106.5 micromol/L | Standard Deviation 1.2 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 56.40 micromol/L | Standard Deviation 2.8 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 147.3 micromol/L | Standard Deviation 4.97 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 63.96 micromol/L | Standard Deviation 1.48 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 117.4 micromol/L | Standard Deviation 5.35 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 83.63 micromol/L | Standard Deviation 49.38 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 164.8 micromol/L | Standard Deviation 64.84 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 220.4 micromol/L | Standard Deviation 103.1 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 248.7 micromol/L | Standard Deviation 120.2 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 182.4 micromol/L | Standard Deviation 80.49 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 77.74 micromol/L | Standard Deviation 53.2 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 58.07 micromol/L | Standard Deviation 8.79 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 137.90 micromol/L | Standard Deviation 33.42 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 113.5 micromol/L | Standard Deviation 3.73 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 122.6 micromol/L | Standard Deviation 13.89 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 56.96 micromol/L | Standard Deviation 2.38 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 160.5 micromol/L | Standard Deviation 47.84 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 3hrs | 71.17 micromol/L | Standard Deviation 10.26 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 7hrs | 303.6 micromol/L | Standard Deviation 158.2 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 4.5hrs | 191.7 micromol/L | Standard Deviation 56.38 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 2 @ 7hrs | 253.0 micromol/L | Standard Deviation 94.4 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 4.5hrs | 205.6 micromol/L | Standard Deviation 71.52 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Phenylalanine | Period 1 @ 3hrs | 70.80 micromol/L | Standard Deviation 2.72 |
Secondary
Plasma Concentration of Proline
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 3hrs | 231.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 270.9 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 7hrs | 268.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 3hrs | 161.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 186.2 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 7hrs | 206.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 135.5 micromol/L | Standard Deviation 36.88 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 3hrs | 212.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 7hrs | 271.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 3hrs | 131.9 micromol/L | Standard Deviation 39.2 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 7hrs | 146.0 micromol/L | Standard Deviation 21.91 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 264.5 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 7hrs | 228.2 micromol/L | Standard Deviation 97.49 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 202.0 micromol/L | Standard Deviation 46.23 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 3hrs | 135.5 micromol/L | Standard Deviation 21.04 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 7hrs | 243.8 micromol/L | Standard Deviation 54.4 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 3hrs | 126.4 micromol/L | Standard Deviation 31.64 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 201.6 micromol/L | Standard Deviation 40.98 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 3hrs | 230.9 micromol/L | Standard Deviation 9.2 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 285.5 micromol/L | Standard Deviation 25.26 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 7hrs | 297.8 micromol/L | Standard Deviation 33.74 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 7hrs | 399.0 micromol/L | Standard Deviation 23.65 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 372.2 micromol/L | Standard Deviation 13.29 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 3hrs | 182.8 micromol/L | Standard Deviation 49 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 3hrs | 177.0 micromol/L | Standard Deviation 73.16 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 315.6 micromol/L | Standard Deviation 131.3 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 275.2 micromol/L | Standard Deviation 43.89 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 1 @ 7hrs | 284.3 micromol/L | Standard Deviation 24.2 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 3hrs | 183.2 micromol/L | Standard Deviation 76.25 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Proline | Period 2 @ 7hrs | 331.3 micromol/L | Standard Deviation 158.1 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 3hrs | 256.3 micromol/L | Standard Deviation 34.95 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 7hrs | 501.8 micromol/L | Standard Deviation 151.6 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 4.5hrs | 454.2 micromol/L | Standard Deviation 113.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 2 @ 7hrs | 506.5 micromol/L | Standard Deviation 150.2 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 4.5hrs | 412.0 micromol/L | Standard Deviation 57.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Proline | Period 1 @ 3hrs | 216.5 micromol/L | Standard Deviation 45.65 |
Secondary
Plasma Concentration of Serine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 3hrs | 112.70 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 142.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 7hrs | 148.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 3hrs | 110.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 107.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 7hrs | 118.0 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 92.09 micromol/L | Standard Deviation 14.88 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 3hrs | 114.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 7hrs | 155.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 3hrs | 92.46 micromol/L | Standard Deviation 0.25 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 7hrs | 107.9 micromol/L | Standard Deviation 3.32 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 132.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 7hrs | 109.6 micromol/L | Standard Deviation 25.36 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 105.1 micromol/L | Standard Deviation 7.08 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 3hrs | 88.03 micromol/L | Standard Deviation 12.96 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 7hrs | 121.9 micromol/L | Standard Deviation 7.28 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 3hrs | 77.91 micromol/L | Standard Deviation 8.55 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 112.0 micromol/L | Standard Deviation 3.11 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 3hrs | 102.7 micromol/L | Standard Deviation 6.77 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 144.0 micromol/L | Standard Deviation 15.52 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 7hrs | 139.5 micromol/L | Standard Deviation 8.22 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 7hrs | 165.1 micromol/L | Standard Deviation 30.39 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 170.6 micromol/L | Standard Deviation 14.82 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 3hrs | 97.72 micromol/L | Standard Deviation 6.94 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 3hrs | 76.12 micromol/L | Standard Deviation 6.26 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 123.6 micromol/L | Standard Deviation 11.21 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 130.2 micromol/L | Standard Deviation 24.73 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 1 @ 7hrs | 120.7 micromol/L | Standard Deviation 32.39 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 3hrs | 77.26 micromol/L | Standard Deviation 9.07 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Serine | Period 2 @ 7hrs | 126.5 micromol/L | Standard Deviation 5.98 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 3hrs | 100.9 micromol/L | Standard Deviation 8.89 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 7hrs | 193.1 micromol/L | Standard Deviation 79.13 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 4.5hrs | 192.3 micromol/L | Standard Deviation 51.81 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 2 @ 7hrs | 211.2 micromol/L | Standard Deviation 75.94 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 4.5hrs | 162.6 micromol/L | Standard Deviation 37.36 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Serine | Period 1 @ 3hrs | 76.13 micromol/L | Standard Deviation 10.25 |
Secondary
Plasma Concentration of Taurine
Time frame: Three times during each 7 hour visit
Population: No data available as no data for this outcome measure were collected during the study.
Secondary
Plasma Concentration of Threonine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 209.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 266.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 260.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 208.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 210.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 223.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 94.60 micromol/L | Standard Deviation 37.36 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 121.9 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 183.8 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 93.40 micromol/L | Standard Deviation 29.19 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 107.5 micromol/L | Standard Deviation 24.62 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 152.3 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 148.4 micromol/L | Standard Deviation 55.95 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 135.2 micromol/L | Standard Deviation 31.78 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 94.87 micromol/L | Standard Deviation 27.61 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 161.6 micromol/L | Standard Deviation 37.56 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 79.93 micromol/L | Standard Deviation 35.53 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 129.1 micromol/L | Standard Deviation 27.9 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 128.8 micromol/L | Standard Deviation 22.22 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 181.3 micromol/L | Standard Deviation 40.39 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 202.6 micromol/L | Standard Deviation 35.7 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 248.5 micromol/L | Standard Deviation 71.49 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 222.4 micromol/L | Standard Deviation 29.51 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 119.5 micromol/L | Standard Deviation 16.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 100.2 micromol/L | Standard Deviation 39.51 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 193.7 micromol/L | Standard Deviation 45.62 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 160.1 micromol/L | Standard Deviation 26.4 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 162.5 micromol/L | Standard Deviation 16.42 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 111.7 micromol/L | Standard Deviation 4.21 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 211.4 micromol/L | Standard Deviation 75.37 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 3hrs | 176.6 micromol/L | Standard Deviation 61.58 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 7hrs | 362.0 micromol/L | Standard Deviation 197 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 4.5hrs | 337.9 micromol/L | Standard Deviation 146.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 2 @ 7hrs | 363.8 micromol/L | Standard Deviation 179.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 4.5hrs | 290.7 micromol/L | Standard Deviation 118.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Threonine | Period 1 @ 3hrs | 154.2 micromol/L | Standard Deviation 24.56 |
Secondary
Plasma Concentration of Tyrosine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 78.10 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 71.64 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 60.88 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 64.19 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 55.47 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 54.80 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 53.42 micromol/L | Standard Deviation 16.6 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 66.48 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 78.05 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 67.08 micromol/L | Standard Deviation 22.47 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 54.88 micromol/L | Standard Deviation 25.08 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 67.91 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 44.42 micromol/L | Standard Deviation 7 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 50.02 micromol/L | Standard Deviation 3.79 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 53.81 micromol/L | Standard Deviation 4.3 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 62.50 micromol/L | Standard Deviation 5.36 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 58.22 micromol/L | Standard Deviation 3.82 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 63.50 micromol/L | Standard Deviation 6.52 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 67.60 micromol/L | Standard Deviation 4.6 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 60.03 micromol/L | Standard Deviation 9.87 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 51.26 micromol/L | Standard Deviation 5.37 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 71.62 micromol/L | Standard Deviation 8.59 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 73.08 micromol/L | Standard Deviation 0.53 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 60.28 micromol/L | Standard Deviation 14.06 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 51.25 micromol/L | Standard Deviation 10.35 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 58.20 micromol/L | Standard Deviation 17.76 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 58.22 micromol/L | Standard Deviation 7.83 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 52.90 micromol/L | Standard Deviation 5.96 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 55.68 micromol/L | Standard Deviation 8.37 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 52.24 micromol/L | Standard Deviation 20.36 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 3hrs | 88.24 micromol/L | Standard Deviation 25.57 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 7hrs | 80.88 micromol/L | Standard Deviation 24.13 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 4.5hrs | 99.76 micromol/L | Standard Deviation 32.81 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 2 @ 7hrs | 105.4 micromol/L | Standard Deviation 46.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 4.5hrs | 86.43 micromol/L | Standard Deviation 19.95 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Tyrosine | Period 1 @ 3hrs | 85.15 micromol/L | Standard Deviation 14.45 |
Secondary
Plasma Concentration of Valine
Time frame: Three times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 3hrs | 187.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 257.6 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 7hrs | 281.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 3hrs | 177.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 208.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 7hrs | 230.1 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 167.8 micromol/L | Standard Deviation 22.42 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 3hrs | 136.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 7hrs | 248.4 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 3hrs | 165.6 micromol/L | Standard Deviation 11.94 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 7hrs | 186.6 micromol/L | Standard Deviation 4.18 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 188.7 micromol/L | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 7hrs | 241.1 micromol/L | Standard Deviation 226.3 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 247.3 micromol/L | Standard Deviation 110 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 3hrs | 177.5 micromol/L | Standard Deviation 88.16 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 7hrs | 356.2 micromol/L | Standard Deviation 63.52 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 3hrs | 159.6 micromol/L | Standard Deviation 44.44 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 260.2 micromol/L | Standard Deviation 50.23 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 3hrs | 177.4 micromol/L | Standard Deviation 38.16 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 282.0 micromol/L | Standard Deviation 8.7 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 7hrs | 332.7 micromol/L | Standard Deviation 27.59 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 7hrs | 433.4 micromol/L | Standard Deviation 31.96 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 323.7 micromol/L | Standard Deviation 45.42 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 3hrs | 171.7 micromol/L | Standard Deviation 9.35 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 3hrs | 179.8 micromol/L | Standard Deviation 45.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 338.1 micromol/L | Standard Deviation 84.89 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 296.2 micromol/L | Standard Deviation 15.89 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 1 @ 7hrs | 353.9 micromol/L | Standard Deviation 17.09 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 3hrs | 199.1 micromol/L | Standard Deviation 7.82 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Concentration of Valine | Period 2 @ 7hrs | 399.8 micromol/L | Standard Deviation 178.2 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 3hrs | 264.2 micromol/L | Standard Deviation 11.62 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 7hrs | 663.9 micromol/L | Standard Deviation 260.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 4.5hrs | 480.9 micromol/L | Standard Deviation 71.82 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 2 @ 7hrs | 635.1 micromol/L | Standard Deviation 159.6 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 4.5hrs | 477.7 micromol/L | Standard Deviation 125.8 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Concentration of Valine | Period 1 @ 3hrs | 245.5 micromol/L | Standard Deviation 3.68 |
Secondary
Plasma Stable Isotope Enrichment of Phenylalanine
Time frame: Twelve times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2. During both periods (1 and 2), samples were not obtained from any subjects at the 0hr time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.15 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.16 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.15 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.15 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.16 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.14 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.14 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.17 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.16 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.14 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.14 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.13 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.15 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.13 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.16 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.10 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.11 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.09 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.08 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.11 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.10 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.10 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.10 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.09 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.08 trace/tracee ratio | Standard Deviation 0.09 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.1 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.08 trace/tracee ratio | Standard Deviation 0.1 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.13 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.13 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.14 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.14 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.13 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.12 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.13 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.12 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.13 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.14 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 7hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 6hrs | 0.10 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 4.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 4hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3.5hrs | 0.49 trace/tracee ratio | Standard Deviation 0.56 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 3hrs | 0.12 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 7hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 6hrs | 0.09 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 2.5hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2.5hrs | 0.11 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 2hrs | 0.10 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 3hrs | 0.12 trace/tracee ratio | Standard Deviation 0.01 |
| Unknown | Plasma Stable Isotope Enrichment of Phenylalanine | Period 2 @ 0hrs | — trace/tracee ratio | — |
| Unknown | Plasma Stable Isotope Enrichment of Phenylalanine | Period 1 @ 0hrs | — trace/tracee ratio | — |
Secondary
Plasma Stable Isotope Enrichment of Tyrosine
Time frame: Twelve times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2. During both periods (1 and 2), samples were not obtained from any subjects at the 0hr time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.07 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.10 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.07 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.07 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.88 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.07 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.07 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.04 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.04 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.03 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.04 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.04 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.04 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.04 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.03 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.05 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.05 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.07 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.07 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.07 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.10 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.10 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.06 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.07 trace/tracee ratio | Standard Deviation 0.02 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.07 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.04 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.05 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.05 trace/tracee ratio | Standard Deviation 0 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.06 trace/tracee ratio | Standard Deviation 0.01 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 7hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3.5hrs | 0.07 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 6hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 4.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 4hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 5.5hrs | 0.09 trace/tracee ratio | Standard Deviation 0.05 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 3hrs | 0.09 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 7hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 6hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 2.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2.5hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 2hrs | 0.07 trace/tracee ratio | Standard Deviation 0.03 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 3hrs | 0.08 trace/tracee ratio | Standard Deviation 0.04 |
| Unknown | Plasma Stable Isotope Enrichment of Tyrosine | Period 2 @ 0hrs | — trace/tracee ratio | — |
| Unknown | Plasma Stable Isotope Enrichment of Tyrosine | Period 1 @ 0hrs | — trace/tracee ratio | — |
Secondary
Serum Concentration of Insulin
Time frame: Five times during each 7 hour visit
Population: One subject completed Period 1, but withdrew from the study prior to the start of Period 2. One subject in grp 0.04 g/kg/hr, seq BA, serum concentration of insulin was not collected at any time point during Period 1. One subject in grp 0.08 g/kg/hr, seq AB, serum concentration of insulin was not collected at the 3hr time point during Period 2.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 6hrs | 24.40 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 5hrs | 21.80 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 7hrs | 90.20 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 6hrs | 73.20 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 5hrs | 102.4 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 4hrs | 87.20 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 4hrs | 23.50 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 3hrs | 13.70 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 3hrs | 7.60 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 7hrs | 20.80 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 4hrs | 60.90 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 3hrs | 4.70 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 5hrs | 63.40 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 6hrs | 70.70 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 7hrs | 64.90 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 3hrs | 7.80 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 4hrs | 7.20 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 5hrs | 5.10 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 6hrs | 5.80 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.04 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 7hrs | 7.90 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 6hrs | 20.95 mciu/mL | Standard Deviation 20.01 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 5hrs | 60.95 mciu/mL | Standard Deviation 1.63 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 3hrs | 14.10 mciu/mL | Standard Deviation 13.29 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 7hrs | 16.60 mciu/mL | Standard Deviation 17.68 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 5hrs | 21.65 mciu/mL | Standard Deviation 23.41 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 4hrs | 19.10 mciu/mL | Standard Deviation 20.36 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 3hrs | 2.10 mciu/mL | Standard Deviation 0 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 6hrs | 67.20 mciu/mL | Standard Deviation 8.49 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 7hrs | 67.90 mciu/mL | Standard Deviation 12.16 |
| 15% CLINISOL 0.08 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 4hrs | 66.50 mciu/mL | Standard Deviation 4.95 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 4hrs | 15.30 mciu/mL | Standard Deviation 0.71 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 5hrs | 12.15 mciu/mL | Standard Deviation 1.77 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 4hrs | 105.2 mciu/mL | Standard Deviation 0.78 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 7hrs | 13.15 mciu/mL | Standard Deviation 4.03 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 6hrs | 17.65 mciu/mL | Standard Deviation 9.26 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 3hrs | 9.95 mciu/mL | Standard Deviation 1.2 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 3hrs | 7.40 mciu/mL | Standard Deviation 0.28 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 7hrs | 92.75 mciu/mL | Standard Deviation 26.09 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 6hrs | 100.9 mciu/mL | Standard Deviation 11.17 |
| 15% CLINISOL 0.08 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 5hrs | 102.0 mciu/mL | Standard Deviation 7.5 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 4hrs | 75.95 mciu/mL | Standard Deviation 23.55 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 6hrs | 9.05 mciu/mL | Standard Deviation 5.3 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 7hrs | 9.35 mciu/mL | Standard Deviation 6.58 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 3hrs | 8.25 mciu/mL | Standard Deviation 2.05 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 3hrs | 6.90 mciu/mL | Standard Deviation 5.8 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 5hrs | 69.85 mciu/mL | Standard Deviation 9.26 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 7hrs | 74.30 mciu/mL | Standard Deviation 15.41 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 2 @ 6hrs | 73.55 mciu/mL | Standard Deviation 6.15 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 5hrs | 12.10 mciu/mL | Standard Deviation 4.95 |
| 15% CLINISOL 0.13 g/kg/hr (AB) | Serum Concentration of Insulin | Period 1 @ 4hrs | 12.60 mciu/mL | Standard Deviation 7.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 3hrs | 66.20 mciu/mL | Standard Deviation 75.24 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 7hrs | 143.0 mciu/mL | Standard Deviation 185.5 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 4hrs | 301.9 mciu/mL | Standard Deviation 206.9 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 5hrs | 259.6 mciu/mL | Standard Deviation 194.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 7hrs | 188.5 mciu/mL | Standard Deviation 128.9 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 4hrs | 139.3 mciu/mL | Standard Deviation 154.1 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 6hrs | 239.4 mciu/mL | Standard Deviation 192.3 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 5hrs | 168.8 mciu/mL | Standard Deviation 206 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 1 @ 3hrs | 27.10 mciu/mL | Standard Deviation 19.37 |
| 15% CLINISOL 0.13 g/kg/hr (BA) | Serum Concentration of Insulin | Period 2 @ 6hrs | 173.0 mciu/mL | Standard Deviation 221.7 |