Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01922973

Enrollment

Registered

2013-08-14

Start date

2003-05-31

Completion date

2004-12-31

Last updated

2013-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Keywords

ghrelin, growth hormone, aging, normal volunteers

Brief summary

The overall objective of this study is to determine the extent to which circulating ghrelin levels (total and bioactive ghrelin) are regulated by nutritional state and age.

Detailed description

Normal volunteers: young and older men and women studied under fed and fasting (total 62.5h) conditions, frequent blood sampling for ghrelin and other related hormones

Interventions

OTHERFasting

normal volunteers fast from food on one occasion for 62.5 h; on another occasion fed 3 meals

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy young (ages 18-30) and older (ages \> 60) men and women with a body mass index (BMI) of \<35 kg/m2. Young and older subjects will be matched for BMI.

Exclusion criteria

1. A history of coronary artery disease, congestive heart failure, peripheral vascular disease, diabetes mellitus, significant hypertension (BP \>180 systolic or \>100 diastolic at rest); renal, hepatic, pulmonary disease; untreated hypothyroidism, untreated hyperthyroidism; history of seizure disorder; history of malignancy (other than some skin cancers), history of active chronic infections (e.g., HIV, tuberculosis): abnormal screening laboratory tests. This information will be obtained through the use of screening labs, history and physical exam and the medical record. See the GCRC protocol for details of the labs. 2. Hematocrit \< 41% men, \< 38% women 3. History of daily tobacco use within past 3 months 4. Chronic alcohol abuse 5. Recent weight change of \> 10 pounds in last 3 months 6. Strenuous exercise for average of more than 60 min/day 7. Investigational drug within past 6 weeks 8. Any history of major psychosis, severe depression, anorexia nervosa 9. Transmeridian travel within 2 weeks prior to or during study -

Design outcomes

Primary

Measure	Time frame
Ghrelin concentration	24-h mean

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026