Gastritis, Gastric Ulcer, and Duodenal Ulcer
Conditions
Keywords
Helicobacter, Eradication
Brief summary
If we compare eradication rate of Helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(AOC), amoxicillin, rabeprazole, metronidazole(AOM), treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days(sequential), amoxicillin, clarithromycin, metronidazole, rabeprazole(concomitant), then the eradication rate of concomitant group will be the highest.
Detailed description
* Subject: The patient of gastritis, gastric ulcer, and duodenal ulcer infected with Helicobacter pylori * 170 subjects per group * Eradication regimens are as follows: AOC group, treated with amoxicillin, rabeprazole, clarithromycin for 7 days; AOM group, treated with amoxicillin, rabeprazole, metronidazole for 7 days; sequential group, treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days; concomitant group, treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days
Interventions
DRUGamoxicillin, clarithromycin, metronidazole, rabeprazole
Sponsors
Bucheon St. Mary's Hospital
St Vincent's Hospital
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* patients infected with Helicobacter pylori
Exclusion criteria
* cancer * pregnancy * formerly treated with eradication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the efficacy of concomitant therapy for eradication of Helicobacter pylori | 6 months (Feb 2014) | measure eradication rate of H.pylori with urea breath test(UBT) after 6 to 8 weeks of treatment |
Countries
South Korea
Outcome results
None listed