Wound Healing of STSG
Conditions
Keywords
STSG, wound healing
Brief summary
To compare the efficacy and safety of negative pressure drainage system with controls (indirect saline soaks) in the coverage of recipient site wounds of split-thickness skin graft.
Detailed description
Randomized, comparator-controlled trial in patients underwent split-thickness skin graft conducted in Taipei Veterans General Hospital between Aug. 2012 and Dec. 2013. (No.) patients age 21 to 60 years were randomly assigned in the intervention group (n= ) of negative pressure drainage system or to a control group (n= ) of traditional method. Patients who had immunologic disease, end-stage renal disease, coagulopathy, or history of radiation were excluded. The conditions of graft take and pain and discomfort were compared every day during the first 7 days after operation and 2 weeks and 3 months follow up.
Interventions
DEVICENegative pressure drainage system
a close system surgical drain was placed over the graft with the length equal to the wound size. A silicon penrose drain with side holes on it covered the surgical drain to prevent direct contact of transparent film and the surgical drain, which led to poor drainage function. The penrose drains were excluded from the system during the test period due to the same function of a close system surgical drain with and without a penrose drain. A transparent film was place over the graft and drains and over a margin of the surrounding healthy skin.
DEVICEIndirect wet dressing
The recipient site wound is covered with sulfa-tula first and then wet gauze.
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Aged 21 to 60 years * The wounds located on limbs or trunk * The area of wounds is ranged 50 to 250cm2.
Exclusion criteria
* immunodeficiency disease * end stage renal disease * coagulopathy * history of radiation to the recipient site * allergy to the dressing * major medical problems
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healing of the wound at the 7th day after operation | 1 week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain, Comfort, and satisfication of the device | one week | — |
| Long term wound condition | three months | Such as area of non-healing, erosion, infection, or scar hypertrophy |
Countries
Taiwan
Outcome results
None listed