Type 2 Diabetes
Conditions
Keywords
Glucose tolerance
Brief summary
The goal of the study is to examine if healthy individuals that ingest St John's wort will have a significantly difference in glucose tolerance.
Interventions
OTHERSt John's wort
Sponsors
University of Southern Denmark
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-40 years * Males * Fasting plasma-glucose \< 7.0 mmol/L * Glycosylated haemoglobin A1c within reference or clinically insignificant deviation hereof * Body mass index \< 30 kg/m\^2
Exclusion criteria
* Hypersensitivity to St John's wort * Chronical or daily alcohol abuse * Known liver disease * Ingestion of drugs requiring prescription, except locally acting drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose area under curve (AUC) 0-2 hours | Glucose concentration 0, 15, 30, 45, 60, 90 and 120 after glucose ingestion | At time=0, the subjects will ingest 75g glucose. Plasma glucose will be measured at 0, 15, 30, 45, 60, 90 and 120 minutes after glucose ingestion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| St John's wort pharmacokinetics | At time=0 | At time=0, the concentration of active components hypericin and hyperforin will be measured. |
| Other metabolic markers | At time points, 0, 15, 30, 45, 60, 90, 120 minutes after glucose ingestion | C-peptide and serum insulin will also be measured during the oral glucose tolerance test. |
Countries
Denmark
Outcome results
None listed